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Peptide record

TPDB21686

Antibacterial Anticancer Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB21686
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
KAAKKAWKAAKKAWKAWKKAA
Physicochemical Analysis
C114H185N33O22
RNDCEQGHILMFPSTYV
AK
2369.93
11.41
9
0
12
+9
1.83
-1.029
42.86
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
16500
696.22
0
Residue Composition
number
9
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
9
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 9 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 9 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
21
C114H185N33O22
2369.93
11.41
+9
1.83
-1.029
Evidence Records 2 records
Evidence 1 Activity

Activity

EC50
Toxicity
20 µM
Cytotoxic
EC50 | 20 | µM | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Relative spatial positions of tryptophan and cationic residues in helical membrane-active peptides determine their cytotoxicity. | J Biol Chem | 2012
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
J Biol Chem. 2012 Jan 2 287(1):233-246.