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Peptide record

TPDB21679

ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Antibacterial Antifungal Antihypertensive iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB21679
ACE inhibitor dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Antibacterial Antifungal Antihypertensive iDPPIV
Anti-infective peptides Cardiometabolic peptides
Peptipedia CAFPdb dbAMP AHTPDB AHTpin iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Antibacterial, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
KA
Physicochemical Analysis
C9H19N3O3
RNDCEQGHILMFPSTWYV
AK
217.27
10.10
1
0
1
+1
0.82
-1.050
50.00
Mammalian: 1.3 hour Yeast: 3 min E.coli: 2 min
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
2
C9H19N3O3
217.27
10.10
+1
0.82
-1.050
217.2647
217.1422
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
31.50 µM
Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Sentandreu M. A., Toldra F.
Evaluation of ACE inhibitory activity of dipeptides generated by the action of porcine muscle dipeptidyl peptidases. Food Chem., 101, 1629-1633, 2007
2007
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)O InChI=1S/C9H19N3O3/c1-6(9(14)15)12-8(13)7(11)4-2-3-5-10/h6-7H,2-5,10-11H2,1H3,(H,12,13)(H,14,15)/t6-,7-/m0/s1 InChIKey: QOOWRKBDDXQRHC-BQBZGAKWSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 3174), the EROP-Moscow database Inhibitor of Leucyltranferase (EC 2.3.2.6) according to the BRENDA database Inhibitor of the bleomycin hydrolase (EC 3.4.22.40) according to the BRENDA database Inhibitor of Dipeptidyl peptidase-III (DPP-III) (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9511)
Evidence 2 Activity

Activity

IC50
Antihypertensive
31.50 µM
Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Sentandreu M. A., Toldra F.
Evaluation of ACE inhibitory activity of dipeptides generated by the action of porcine muscle dipeptidyl peptidases. Food Chem., 101, 1629-1633, 2007
2007
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)O InChI=1S/C9H19N3O3/c1-6(9(14)15)12-8(13)7(11)4-2-3-5-10/h6-7H,2-5,10-11H2,1H3,(H,12,13)(H,14,15)/t6-,7-/m0/s1 InChIKey: QOOWRKBDDXQRHC-BQBZGAKWSA-N Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 3174), the EROP-Moscow database Inhibitor of Leucyltranferase (EC 2.3.2.6) according to the BRENDA database Inhibitor of the bleomycin hydrolase (EC 3.4.22.40) according to the BRENDA database Inhibitor of Dipeptidyl peptidase-III (DPP-III) (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9511)
Evidence 3 Activity

Activity

IC50
iDPPIV
6270.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Gallego M., Aristoy M.-C., Toldrá F.
Dipeptidyl peptidase IV inhibitory peptides generated in Spanish dry-cured ham. Meat Science, 96, 757-761, 2014
2014
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)O InChI=1S/C9H19N3O3/c1-6(9(14)15)12-8(13)7(11)4-2-3-5-10/h6-7H,2-5,10-11H2,1H3,(H,12,13)(H,14,15)/t6-,7-/m0/s1 InChIKey: QOOWRKBDDXQRHC-BQBZGAKWSA-N First note concerning peptide: Bella A. M., Erickson R. H. Jr., Kim Y. S. Rat intestinal brush border membrane dipeptidyl-aminopeptidase IV:kinetic properties and substrate specifities of the purified enzyme. Arch. Biochem. Biophys. 218 (1), 156-162 (1982) Inhibitor of angiotensin-converting enzyme (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BindingDB database, the BIOPEP-UWM database of bioactive peptides (ID 7743), the BRENDA database, the ChEMBL database, the EROP-Moscow database the PubChem database Inhibitor of Leucyltranferase (EC 2.3.2.6) according to the BRENDA database Inhibitor of the bleomycin hydrolase (EC 3.4.22.40) according to the BRENDA database Inhibitor of Dipeptidyl peptidase-III (DPP-III) (EC 3.4.14.4) (MEROPS ID: M49.001) according to the BIOPEP-UWM database of bioactive peptides (ID 9511)
Additional Detail Fields 1 fields
2