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Peptide record

TPDB21651

Antibacterial Antifungal Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB21651
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb ToxinPred 3.0
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and ToxinPred 3.0, with an available 3D structural model.
Sequence
IWLTKALKFLGKNLGK
Physicochemical Analysis
C89H148N22O19
RDCEQHMPSYV
LK
1830.29
11.00
4
0
8
+4
-1.16
0.175
128.12
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
300.50
2
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
4
L
4
K
0
M
1
F
0
P
0
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 4 K: 4 M: 0 F: 1 P: 0 S: 0 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
16
C89H148N22O19
1830.29
11.00
+4
-1.16
0.175
Evidence Records 5 records
Evidence 1 Activity

Activity

1% Hemolysis
Toxicity
44.67 µM
Hemolytic Cytotoxic
1% Hemolysis | 44.67 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Shortened derivatives from native antimicrobial peptide LyeTx I: In vitro and in vivo biological activity assessment. | Exp Biol Med (Maywood) | 2021
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
506.5 µM
Hemolytic Cytotoxic
50% Hemolysis | 506.5 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Shortened derivatives from native antimicrobial peptide LyeTx I: In vitro and in vivo biological activity assessment. | Exp Biol Med (Maywood) | 2021
Evidence 3 Activity

Activity

50% Killing
Toxicity
11.84 µM
Cytotoxic
50% Killing | 11.84 | µM | target cell: Lund human mesencephalic (LUHMES) cells

Target

Lund human mesencephalic (LUHMES) cells

Source & Reference

NA
DBAASP
Shortened derivatives from native antimicrobial peptide LyeTx I: In vitro and in vivo biological activity assessment. | Exp Biol Med (Maywood) | 2021
Evidence 4 Activity

Activity

1% Hemolysis
Toxicity
27.44 µM
Hemolytic Cytotoxic
1% Hemolysis | 27.44 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Shortened derivatives from native antimicrobial peptide LyeTx I: In vitro and in vivo biological activity assessment. | Exp Biol Med (Maywood) | 2021
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
207.5 µM
Hemolytic Cytotoxic
50% Hemolysis | 207.5 | µM | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Shortened derivatives from native antimicrobial peptide LyeTx I: In vitro and in vivo biological activity assessment. | Exp Biol Med (Maywood) | 2021