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Peptide record

TPDB21648

Antibacterial Toxicity standard

13 amino acids

3D PDB MODEL

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TPDB ID TPDB21648

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

IWLLLLKKFWKKW

FASTA

>TPDB21648|Antibacterial;Toxicity|length=13
IWLLLLKKFWKKW

Formula C96H144N20O14

Absent Amino Acids ARNDCEQGHMPSTYV

Common Amino Acids LK

Mass 1802.32

PI 11.00

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +4

Boman Index -5.27

Hydrophobicity 0.323

Aliphatic Index 150.00

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 16500

Absorbance 280nm 915.48

Polar Residues 0

number

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 4 K: 4 M: 0 F: 1 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0

Length

Formula

C96H144N20O14

Mass

1802.32

11.00

Net Charge

Boman Index

-5.27

Hydrophobicity

0.323

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.13 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli (MIC 3.13 uM), P. aeruginosa (MIC 6.25 uM), E. aerogenes (MIC 1.56 uM), E. cloacae (MIC 6.25 uM), K. pn

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli (MIC 3.13 uM), P. aeruginosa (MIC 6.25 uM), E. aerogenes (MIC 1.56 uM), E. cloacae (MIC 6.25 uM), K. pneumoniae (MIC 6.25 uM), S. au

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.56 µM

Target

Target Organism Enterobacter aerogenes

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli (MIC 3.13 uM), P. aeruginosa (MIC 6.25 uM), E. aerogenes (MIC 1.56 uM), E. cloacae (MIC 6.25 uM), K. pneumoniae (MIC 6.25 uM), S. aureus (MIC 0.78 uM), B. cereu

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µM

Target

Target Organism Enterobacter cloacae

Source & Reference

Database Source NA

Other

Evidence Text

e against E. coli (MIC 3.13 uM), P. aeruginosa (MIC 6.25 uM), E. aerogenes (MIC 1.56 uM), E. cloacae (MIC 6.25 uM), K. pneumoniae (MIC 6.25 uM), S. aureus (MIC 0.78 uM), B. cereus (MIC 3.13 uM), S. lactis

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source NA

Other

Evidence Text

3 uM), P. aeruginosa (MIC 6.25 uM), E. aerogenes (MIC 1.56 uM), E. cloacae (MIC 6.25 uM), K. pneumoniae (MIC 6.25 uM), S. aureus (MIC 0.78 uM), B. cereus (MIC 3.13 uM), S. lactis (MIC 1.56 uM), E. faecalis (

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.78 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

5 uM), E. aerogenes (MIC 1.56 uM), E. cloacae (MIC 6.25 uM), K. pneumoniae (MIC 6.25 uM), S. aureus (MIC 0.78 uM), B. cereus (MIC 3.13 uM), S. lactis (MIC 1.56 uM), E. faecalis (MIC 12.5 uM), E. faecium

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.13 µM

Target

Target Organism B. cereus

Source & Reference

Database Source NA

Other

Evidence Text

1.56 uM), E. cloacae (MIC 6.25 uM), K. pneumoniae (MIC 6.25 uM), S. aureus (MIC 0.78 uM), B. cereus (MIC 3.13 uM), S. lactis (MIC 1.56 uM), E. faecalis (MIC 12.5 uM), E. faecium (MIC 6.25 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.56 µM

Target

Target Organism S. lactis

Source & Reference

Database Source NA

Other

Evidence Text

6.25 uM), K. pneumoniae (MIC 6.25 uM), S. aureus (MIC 0.78 uM), B. cereus (MIC 3.13 uM), S. lactis (MIC 1.56 uM), E. faecalis (MIC 12.5 uM), E. faecium (MIC 6.25 uM).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 12.5 µM

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source NA

Other

Evidence Text

(MIC 6.25 uM), S. aureus (MIC 0.78 uM), B. cereus (MIC 3.13 uM), S. lactis (MIC 1.56 uM), E. faecalis (MIC 12.5 uM), E. faecium (MIC 6.25 uM).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µM

Target

Target Organism E. faecium

Source & Reference

Database Source NA

Other

Evidence Text

IC 0.78 uM), B. cereus (MIC 3.13 uM), S. lactis (MIC 1.56 uM), E. faecalis (MIC 12.5 uM), E. faecium (MIC 6.25 uM).

Evidence 11 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 6.25 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 6.25 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Membrane mechanism of temporin-1CEc, an antimicrobial peptide isolated from the skin secretions of Rana chensinensis, and its systemic analogs. | Bioorg Chem | 2022