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Peptide record

TPDB21627

Antibacterial Antifungal standard
42 amino acids
Basic Information
3D PDB MODEL
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TPDB21627
Antibacterial Antifungal
Anti-infective peptides
Peptipedia AFP-GFuse Antifungipept CAFPdb
standard
No
A 42-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia, AFP-GFuse, Antifungipept, and other sources, with an available 3D structural model.
Sequence
ITISNSSFGRIVYWNCKTDKDCKQHRGFNFRCRSGNCIPIRR
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C214H339N71O59S4
AELM
R
4978.73
10.45
10
2
11
+7
3.13
-0.736
53.33
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
7240
1.45
16
Residue Composition
number
0
A
6
R
4
N
2
D
4
C
0
E
1
Q
3
G
1
H
5
I
0
L
3
K
0
M
3
F
1
P
4
S
2
T
1
W
1
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 4 D: 2 C: 4 E: 0 Q: 1 G: 3 H: 1 I: 5 L: 0 K: 3 M: 0 F: 3 P: 1 S: 4 T: 2 W: 1 Y: 1 V: 1
Chemical Descriptors
42 reviewed residue count
C214H339N71O59S4 sequence-only estimate (linear, free termini)
4978.73 sequence-only estimate (linear, free termini)
10.45 sequence-only estimate (linear, free termini)
+7 sequence-only estimate (linear, free termini)
3.13 sequence-only estimate (linear, free termini)
-0.736 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

Active against C. albicans strains WO-1 and Sc5314 (MIC 19 and 12.5 ug/ml).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

CAFPdb Antifungipept

Other

Active against C. albicans strains WO-1 and Sc5314 (MIC 19 and 12.5 ug/ml).