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Peptide record

TPDB21575

Antibacterial Anticancer Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB21575
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 21-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
IRAWAKVLKGVGKILKGVGRW
Physicochemical Analysis
C111H187N33O22
NDCEQHMFPSTY
GK
2335.91
12.44
6
0
11
+6
0.05
0.229
125.24
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
11000
470.91
0
Residue Composition
number
2
A
2
R
0
N
0
D
0
C
0
E
0
Q
4
G
0
H
2
I
2
L
4
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
3
V
Amino Acid Distribution
A: 2 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 0 I: 2 L: 2 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 3
Chemical Descriptors
21
C111H187N33O22
2335.91
12.44
+6
0.05
0.229
Evidence Records 3 records
Evidence 1 Activity

Activity

EC50
Toxicity
6.3 µM
Cytotoxic
EC50 | 6.3 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
Simulated Molecular Evolution for Anticancer Peptide Design. | Angew Chem Int Ed Engl | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
136±3 µM
Hemolytic Cytotoxic
50% Hemolysis | 136±3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Simulated Molecular Evolution for Anticancer Peptide Design. | Angew Chem Int Ed Engl | 2019
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Angew Chem Int Ed Engl. 2019 Feb 4 58(6):1674-1684.