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Peptide record

TPDB21560

Antibacterial Anticancer Antifungal Toxicity modified_plain modified
14 amino acids
Basic Information
3D PDB MODEL
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TPDB21560
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 14-aa modified multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
INLKKLAKLXKKIL
Physicochemical Analysis
C73H139N19O15
RDCEQGHMFPSTWYV
K
1523.02
11.12
5
0
7
+5
2.34
0.214
174.29
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
4
L
5
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 4 K: 5 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
14
C73H139N19O15
1523.02
11.12
+5
2.34
0.214
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Cytotoxicity
Toxicity
19.1-20.6 µg/mL
Cytotoxic
50% Cytotoxicity | 19.1-20.6 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
The cationic tetradecapeptide mastoparan as a privileged structure for drug discovery: Enhanced antimicrobial properties of mitoparan analogues modified at position-14. | Peptides | 2018
Evidence 2 Activity

Activity

85.4-86.5% Cytotoxicity
Toxicity
32 µg/mL
Cytotoxic
85.4-86.5% Cytotoxicity | 32 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
The cationic tetradecapeptide mastoparan as a privileged structure for drug discovery: Enhanced antimicrobial properties of mitoparan analogues modified at position-14. | Peptides | 2018
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Bioconjug Chem. 2012 Jan 18 23(1):47-56.