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Peptide record

TPDB21556

Antibacterial Antifungal Toxicity standard

14 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB21556

Activity

Antibacterial Antifungal Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia CAFPdb ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 14-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and ToxinPred 3.0, with an available 3D structural model.

Sequence

INLRAIAALAKKLL

FASTA

>TPDB21556|Antibacterial;Antifungal;Toxicity|length=14
INLRAIAALAKKLL

Formula C70H130N20O16

Absent Amino Acids DCEQGHMFPSTWYV

Common Amino Acids AL

Mass 1507.93

PI 11.64

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 10

Net Charge +3

Boman Index -0.33

Hydrophobicity 1.114

Aliphatic Index 195.71

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 1

number

Amino Acid Distribution

A: 4 R: 1 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 4 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0

Length

Formula

C70H130N20O16

Mass

1507.93

11.64

Net Charge

Boman Index

-0.33

Hydrophobicity

1.114

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

Active against S. aureus (MIC 16 ug/ml), and E. coli (MIC 16 ug/ml), and C. albicans (MIC 64 ug/ml). Reg. 7/2021

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

Active against S. aureus (MIC 16 ug/ml), and E. coli (MIC 16 ug/ml), and C. albicans (MIC 64 ug/ml). Reg. 7/2021

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source NA

Other

Evidence Text

Active against S. aureus (MIC 16 ug/ml), and E. coli (MIC 16 ug/ml), and C. albicans (MIC 64 ug/ml). Reg. 7/2021

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source CAFPdb

Other

Evidence Text

Active against S. aureus (MIC 16 ug/ml), and E. coli (MIC 16 ug/ml), and C. albicans (MIC 64 ug/ml). Reg. 7/2021

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source CAFPdb

Other

Evidence Text

Active against S. aureus (MIC 16 ug/ml), and E. coli (MIC 16 ug/ml), and C. albicans (MIC 64 ug/ml). Reg. 7/2021

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 64 µg/mL

Target

Target Organism Candida albicans

Source & Reference

Database Source CAFPdb

Other

Evidence Text

Active against S. aureus (MIC 16 ug/ml), and E. coli (MIC 16 ug/ml), and C. albicans (MIC 64 ug/ml). Reg. 7/2021

Evidence 7 Activity

Activity

Activity Endpoint 2.294±0.005% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 256 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

2.294±0.005% Hemolysis | 256 | µg/mL | target cell: Sheep erythrocytes

Target

Target Cell Sheep erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Functional characterization, antimicrobial effects, and potential antibacterial mechanisms of new mastoparan peptides from hornet venom (Vespa ducalis, Vespa mandarinia, and Vespa affinis). | Toxicon | 2021