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Peptide record

TPDB21525

Antibacterial Antifungal Toxicity modified_plain modified
13 amino acids
Basic Information
3D PDB MODEL
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TPDB21525
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 13-aa modified multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
ILXWKWXWWXWRR
Physicochemical Analysis
C85H110N22O11
ANDCEQGHMFPSTYV
W
1615.95
12.41
3
0
7
+3
-7.51
-0.700
60.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
27500
1701.79
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
1
K
0
M
0
F
0
P
0
S
0
T
5
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 5 Y: 0 V: 0
Chemical Descriptors
13
C85H110N22O11
1615.95
12.41
+3
-7.51
-0.700
Evidence Records 2 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
<5% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cathelicidin-derived Trp/Pro-rich antimicrobial peptides with lysine peptoid residue (Nlys): therapeutic index and plausible mode of action | J Pept Sci | 2007
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
33.3±12.91 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 33.3±12.91 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Indolicidin analogs with broad-spectrum antimicrobial activity and low hemolytic activity | Peptides | 2020