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Peptide record

TPDB21479

Antibacterial Anticancer Toxicity modified_plain modified
13 amino acids
Basic Information
3D PDB MODEL
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TPDB21479
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 13-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
ILPWKWKWXPWRR
Physicochemical Analysis
C90H126N24O13
ANDCEQGHMFSTYV
W
1752.14
12.42
4
0
6
+4
-3.77
-1.177
60.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
22000
1255.60
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
1
L
2
K
0
M
0
F
2
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 1 K: 2 M: 0 F: 0 P: 2 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
13
C90H126N24O13
1752.14
12.42
+4
-3.77
-1.177
Evidence Records 2 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
>400 µM
Hemolytic Cytotoxic
5% Hemolysis | >400 | µM | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Design of therapeutically improved analogue of the antimicrobial peptide, indolicidin, using a glycosylation strategy. | Amino Acids | 2019
Evidence 2 Activity

Activity

LD50
Toxicity
64 µM
Cytotoxic
LD50 | 64 | µM | target cell: Murine macrophage cells J774A.1

Target

Murine macrophage cells J774A.1

Source & Reference

NA
DBAASP
Design of therapeutically improved analogue of the antimicrobial peptide, indolicidin, using a glycosylation strategy. | Amino Acids | 2019