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Peptide record

TPDB21391

Antibacterial Antifungal Toxicity standard
40 amino acids
Basic Information
3D PDB MODEL
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TPDB21391
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia AFP-GFuse
standard
No
A 40-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia and AFP-GFuse, with an available 3D structural model.
Sequence
ILGRLRDLLRRGGRKIGQGLERIGQRIQGFFSNREPMEES
Physicochemical Analysis
C199H337N69O57S1
ACHTWYV
R
4640.35
11.93
9
5
12
+4
13.19
-0.823
87.75
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
6
Residue Composition
number
0
A
8
R
1
N
1
D
0
C
4
E
3
Q
7
G
0
H
4
I
5
L
1
K
1
M
2
F
1
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 8 N: 1 D: 1 C: 0 E: 4 Q: 3 G: 7 H: 0 I: 4 L: 5 K: 1 M: 1 F: 2 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
40
C199H337N69O57S1
4640.35
11.93
+4
13.19
-0.823
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.9 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

active against Gram- bacteria E. coli ATCC 25922 (MIC 3.9 uM), P-aeruginosa ATCC 27853 (MIC >8.6 uM), S-enterica serovar Typhimurium ATCC 14028 (MIC >8
Evidence 2 Activity

Activity

MIC
Antibacterial
1.1 µM

Target

A. baumannii KCTC 23254

Source & Reference

NA

Other

ginosa ATCC 27853 (MIC >8.6 uM), S-enterica serovar Typhimurium ATCC 14028 (MIC >8.6 uM), A. baumannii KCTC 23254 (MIC 1.1 uM), K. pneumoniae subsp. pneumoniae KCTC 1726 (MIC 7.3 uM), E-cloacae subsp. cloacae ATCC 13
Evidence 3 Activity

Activity

MIC
Antibacterial
7.3 µM

Target

p. pneumoniae KCTC 1726

Source & Reference

NA

Other

imurium ATCC 14028 (MIC >8.6 uM), A. baumannii KCTC 23254 (MIC 1.1 uM), K. pneumoniae subsp. pneumoniae KCTC 1726 (MIC 7.3 uM), E-cloacae subsp. cloacae ATCC 13047 (MIC >8.6 uM), Gram+ bacteria S. aureus ATCC 6538 (M
Evidence 4 Activity

Activity

MIC
Antibacterial
>8.6 µM

Target

p. cloacae ATCC 13047

Source & Reference

NA

Other

23254 (MIC 1.1 uM), K. pneumoniae subsp. pneumoniae KCTC 1726 (MIC 7.3 uM), E-cloacae subsp. cloacae ATCC 13047 (MIC >8.6 uM), Gram+ bacteria S. aureus ATCC 6538 (MIC 5.6 uM), B. cereus ATCC 10876 (MIC 5.4 uM), E-fa
Evidence 5 Activity

Activity

MIC
Antibacterial
5.6 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

NA

Other

KCTC 1726 (MIC 7.3 uM), E-cloacae subsp. cloacae ATCC 13047 (MIC >8.6 uM), Gram+ bacteria S. aureus ATCC 6538 (MIC 5.6 uM), B. cereus ATCC 10876 (MIC 5.4 uM), E-faecalis ATCC 29212 (MIC > 8.6 uM), S-agalactiae AT
Evidence 6 Activity

Activity

MIC
Antibacterial
5.4 µM

Target

B. cereus ATCC 10876

Source & Reference

NA

Other

subsp. cloacae ATCC 13047 (MIC >8.6 uM), Gram+ bacteria S. aureus ATCC 6538 (MIC 5.6 uM), B. cereus ATCC 10876 (MIC 5.4 uM), E-faecalis ATCC 29212 (MIC > 8.6 uM), S-agalactiae ATCC 27956 (MIC >8.6 uM), S-dysgalact
Evidence 7 Activity

Activity

MIC
Antibacterial
>8.6 µM

Target

p. zooepidemicus ATCC 43079

Source & Reference

NA

Other

-agalactiae ATCC 27956 (MIC >8.6 uM), S-dysgalactiae ATCC 27957 (MIC >8.6 uM), S-equi subsp. zooepidemicus ATCC 43079 (MIC >8.6 uM). Also active against C-albicans KCTC 7270 (MIC >8.6 uM) and C. cuniculi KCTC 17232 (MIC 9
Evidence 8 Activity

Activity

MIC
Antibacterial
9.7 µM

Target

C. cuniculi KCTC 17232

Source & Reference

NA

Other

icus ATCC 43079 (MIC >8.6 uM). Also active against C-albicans KCTC 7270 (MIC >8.6 uM) and C. cuniculi KCTC 17232 (MIC 9.7 uM).
Evidence 9 Activity

Activity

MIC
Antifungal
3.9 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

active against Gram- bacteria E. coli ATCC 25922 (MIC 3.9 uM), P-aeruginosa ATCC 27853 (MIC >8.6 uM), S-enterica serovar Typhimurium ATCC 14028 (MIC >8
Evidence 10 Activity

Activity

MIC
Antifungal
1.1 µM

Target

A. baumannii KCTC 23254

Source & Reference

NA

Other

ginosa ATCC 27853 (MIC >8.6 uM), S-enterica serovar Typhimurium ATCC 14028 (MIC >8.6 uM), A. baumannii KCTC 23254 (MIC 1.1 uM), K. pneumoniae subsp. pneumoniae KCTC 1726 (MIC 7.3 uM), E-cloacae subsp. cloacae ATCC 13
Evidence 11 Activity

Activity

MIC
Antifungal
7.3 µM

Target

p. pneumoniae KCTC 1726

Source & Reference

NA

Other

imurium ATCC 14028 (MIC >8.6 uM), A. baumannii KCTC 23254 (MIC 1.1 uM), K. pneumoniae subsp. pneumoniae KCTC 1726 (MIC 7.3 uM), E-cloacae subsp. cloacae ATCC 13047 (MIC >8.6 uM), Gram+ bacteria S. aureus ATCC 6538 (M
Evidence 12 Activity

Activity

MIC
Antifungal
>8.6 µM

Target

p. cloacae ATCC 13047

Source & Reference

NA

Other

23254 (MIC 1.1 uM), K. pneumoniae subsp. pneumoniae KCTC 1726 (MIC 7.3 uM), E-cloacae subsp. cloacae ATCC 13047 (MIC >8.6 uM), Gram+ bacteria S. aureus ATCC 6538 (MIC 5.6 uM), B. cereus ATCC 10876 (MIC 5.4 uM), E-fa
Evidence 13 Activity

Activity

MIC
Antifungal
5.6 µM

Target

Staphylococcus aureus ATCC 6538

Source & Reference

NA

Other

KCTC 1726 (MIC 7.3 uM), E-cloacae subsp. cloacae ATCC 13047 (MIC >8.6 uM), Gram+ bacteria S. aureus ATCC 6538 (MIC 5.6 uM), B. cereus ATCC 10876 (MIC 5.4 uM), E-faecalis ATCC 29212 (MIC > 8.6 uM), S-agalactiae AT
Evidence 14 Activity

Activity

MIC
Antifungal
5.4 µM

Target

B. cereus ATCC 10876

Source & Reference

NA

Other

subsp. cloacae ATCC 13047 (MIC >8.6 uM), Gram+ bacteria S. aureus ATCC 6538 (MIC 5.6 uM), B. cereus ATCC 10876 (MIC 5.4 uM), E-faecalis ATCC 29212 (MIC > 8.6 uM), S-agalactiae ATCC 27956 (MIC >8.6 uM), S-dysgalact
Evidence 15 Activity

Activity

MIC
Antifungal
>8.6 µM

Target

p. zooepidemicus ATCC 43079

Source & Reference

NA

Other

-agalactiae ATCC 27956 (MIC >8.6 uM), S-dysgalactiae ATCC 27957 (MIC >8.6 uM), S-equi subsp. zooepidemicus ATCC 43079 (MIC >8.6 uM). Also active against C-albicans KCTC 7270 (MIC >8.6 uM) and C. cuniculi KCTC 17232 (MIC 9
Evidence 16 Activity

Activity

MIC
Antifungal
9.7 µM

Target

C. cuniculi KCTC 17232

Source & Reference

NA

Other

icus ATCC 43079 (MIC >8.6 uM). Also active against C-albicans KCTC 7270 (MIC >8.6 uM) and C. cuniculi KCTC 17232 (MIC 9.7 uM).
Evidence 17 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Genomewide Analysis and Biological Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity from Three Bat Species | Antibiotics (Basel) | 2022