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Peptide record

TPDB21379

Antibacterial Antifungal Antiparasitic Hemolysis Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB21379
Antibacterial Antifungal Antiparasitic Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb Hemolytic2
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from Peptipedia, CAFPdb, and Hemolytic2, with an available 3D structural model.
Sequence
ILGPVLGLVGSALGGLLKKI
Physicochemical Analysis
C91H164N22O22
RNDCEQHMFTWY
L
1918.44
10.60
2
0
11
+2
-1.40
1.490
190.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
1
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
5
G
0
H
2
I
6
L
2
K
0
M
0
F
1
P
1
S
0
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 5 H: 0 I: 2 L: 6 K: 2 M: 0 F: 0 P: 1 S: 1 T: 0 W: 0 Y: 0 V: 2
Chemical Descriptors
20
C91H164N22O22
1918.44
10.60
+2
-1.40
1.490
Evidence Records 20 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2-8 µM

Target

Staphylococcus aureus ATCC 6538 or MRSA NCTC 12493

Source & Reference

NA

Other

active against S. aureus ATCC 6538 or 5 strains MRSA NCTC 12493 (MIC 2-8 uM), E. faecalis NCTC 12697 (MIC 8 uM), E. coli ATCC 8739 (MIC 4 uM), K. pneumoniae ATCC 4381
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µM

Target

Enterococcus faecalis NCTC 12697

Source & Reference

NA

Other

active against S. aureus ATCC 6538 or 5 strains MRSA NCTC 12493 (MIC 2-8 uM), E. faecalis NCTC 12697 (MIC 8 uM), E. coli ATCC 8739 (MIC 4 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 90
Evidence 3 Activity

Activity

MIC
Antibacterial
4 µM

Target

Escherichia coli ATCC 8739

Source & Reference

NA

Other

s ATCC 6538 or 5 strains MRSA NCTC 12493 (MIC 2-8 uM), E. faecalis NCTC 12697 (MIC 8 uM), E. coli ATCC 8739 (MIC 4 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 8 uM), and A. baumanni
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µM

Target

Klebsiella pneumoniae ATCC 43816

Source & Reference

NA

Other

NCTC 12493 (MIC 2-8 uM), E. faecalis NCTC 12697 (MIC 8 uM), E. coli ATCC 8739 (MIC 4 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 8 uM), and A. baumannii BAA 747 (MIC 32 uM). MBC is the sam
Evidence 5 Activity

Activity

MIC
Antibacterial
8 µM

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

NA

Other

NCTC 12697 (MIC 8 uM), E. coli ATCC 8739 (MIC 4 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 8 uM), and A. baumannii BAA 747 (MIC 32 uM). MBC is the same or higher than MIC.
Evidence 6 Activity

Activity

MIC
Antibacterial
32 µM

Target

A. baumannii BAA 747

Source & Reference

NA

Other

(MIC 4 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 8 uM), and A. baumannii BAA 747 (MIC 32 uM). MBC is the same or higher than MIC.
Evidence 7 Activity

Activity

MIC
Antifungal
2-8 µM

Target

Staphylococcus aureus ATCC 6538 or MRSA NCTC 12493

Source & Reference

CAFPdb

Other

active against S. aureus ATCC 6538 or 5 strains MRSA NCTC 12493 (MIC 2-8 uM), E. faecalis NCTC 12697 (MIC 8 uM), E. coli ATCC 8739 (MIC 4 uM), K. pneumoniae ATCC 4381
Evidence 8 Activity

Activity

MIC
Antifungal
8 µM

Target

Enterococcus faecalis NCTC 12697

Source & Reference

CAFPdb

Other

active against S. aureus ATCC 6538 or 5 strains MRSA NCTC 12493 (MIC 2-8 uM), E. faecalis NCTC 12697 (MIC 8 uM), E. coli ATCC 8739 (MIC 4 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 90
Evidence 9 Activity

Activity

MIC
Antifungal
4 µM

Target

Escherichia coli ATCC 8739

Source & Reference

CAFPdb

Other

s ATCC 6538 or 5 strains MRSA NCTC 12493 (MIC 2-8 uM), E. faecalis NCTC 12697 (MIC 8 uM), E. coli ATCC 8739 (MIC 4 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 8 uM), and A. baumanni
Evidence 10 Activity

Activity

MIC
Antifungal
8 µM

Target

Klebsiella pneumoniae ATCC 43816

Source & Reference

CAFPdb

Other

NCTC 12493 (MIC 2-8 uM), E. faecalis NCTC 12697 (MIC 8 uM), E. coli ATCC 8739 (MIC 4 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 8 uM), and A. baumannii BAA 747 (MIC 32 uM). MBC is the sam
Evidence 11 Activity

Activity

MIC
Antifungal
8 µM

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

CAFPdb

Other

NCTC 12697 (MIC 8 uM), E. coli ATCC 8739 (MIC 4 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 8 uM), and A. baumannii BAA 747 (MIC 32 uM). MBC is the same or higher than MIC.
Evidence 12 Activity

Activity

MIC
Antifungal
32 µM

Target

A. baumannii BAA 747

Source & Reference

CAFPdb

Other

(MIC 4 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 8 uM), and A. baumannii BAA 747 (MIC 32 uM). MBC is the same or higher than MIC.
Evidence 13 Activity

Activity

MIC
Antiparasitic
2-8 µM

Target

Staphylococcus aureus ATCC 6538 or MRSA NCTC 12493

Source & Reference

NA

Other

active against S. aureus ATCC 6538 or 5 strains MRSA NCTC 12493 (MIC 2-8 uM), E. faecalis NCTC 12697 (MIC 8 uM), E. coli ATCC 8739 (MIC 4 uM), K. pneumoniae ATCC 4381
Evidence 14 Activity

Activity

MIC
Antiparasitic
8 µM

Target

Enterococcus faecalis NCTC 12697

Source & Reference

NA

Other

active against S. aureus ATCC 6538 or 5 strains MRSA NCTC 12493 (MIC 2-8 uM), E. faecalis NCTC 12697 (MIC 8 uM), E. coli ATCC 8739 (MIC 4 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 90
Evidence 15 Activity

Activity

MIC
Antiparasitic
4 µM

Target

Escherichia coli ATCC 8739

Source & Reference

NA

Other

s ATCC 6538 or 5 strains MRSA NCTC 12493 (MIC 2-8 uM), E. faecalis NCTC 12697 (MIC 8 uM), E. coli ATCC 8739 (MIC 4 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 8 uM), and A. baumanni
Evidence 16 Activity

Activity

MIC
Antiparasitic
8 µM

Target

Klebsiella pneumoniae ATCC 43816

Source & Reference

NA

Other

NCTC 12493 (MIC 2-8 uM), E. faecalis NCTC 12697 (MIC 8 uM), E. coli ATCC 8739 (MIC 4 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 8 uM), and A. baumannii BAA 747 (MIC 32 uM). MBC is the sam
Evidence 17 Activity

Activity

MIC
Antiparasitic
8 µM

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

NA

Other

NCTC 12697 (MIC 8 uM), E. coli ATCC 8739 (MIC 4 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 8 uM), and A. baumannii BAA 747 (MIC 32 uM). MBC is the same or higher than MIC.
Evidence 18 Activity

Activity

MIC
Antiparasitic
32 µM

Target

A. baumannii BAA 747

Source & Reference

NA

Other

(MIC 4 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 8 uM), and A. baumannii BAA 747 (MIC 32 uM). MBC is the same or higher than MIC.
Evidence 19 Activity

Activity

50% Hemolysis
Toxicity
17.2 µM
Hemolytic Cytotoxic
50% Hemolysis | 17.2 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Discovery and Optimisation of Novel Bombinin-Derived Peptides from Bombina variegata against Staphylococcus aureus. | Probiotics Antimicrob Proteins | 2025
Evidence 20 Activity

Activity

IC50
Toxicity
29.8 µM
Cytotoxic
IC50 | 29.8 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Discovery and Optimisation of Novel Bombinin-Derived Peptides from Bombina variegata against Staphylococcus aureus. | Probiotics Antimicrob Proteins | 2025