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Peptide record

TPDB21343

Antibacterial Anticancer Cell-penetrating Peptides Hemolysis Toxicity standard
16 amino acids
Basic Information
3D PDB MODEL
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TPDB21343
Antibacterial Anticancer Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
Peptipedia HemoPI Hemolytic2 PD_Hemolysis
standard
No
A 16-aa standard natural multi-activity (Antibacterial, Anticancer, Cell-penetrating Peptides, and other sources) peptide sequence curated from Peptipedia, HemoPI, Hemolytic2, and other sources, with an available 3D structural model.
Sequence
ILGKLLSTAWGLLSNL
Physicochemical Analysis
C80H135N19O21
RDCEQHMFPYV
L
1699.07
10.10
1
0
9
+1
-3.86
1.106
176.88
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
323.71
4
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
0
E
0
Q
2
G
0
H
1
I
6
L
1
K
0
M
0
F
0
P
2
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 6 K: 1 M: 0 F: 0 P: 0 S: 2 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
16
C80H135N19O21
1699.07
10.10
+1
-3.86
1.106
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
11 µM
Hemolytic Cytotoxic
50% Hemolysis | 11 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Transformation of the naturally occurring frog skin peptide, alyteserin-2a into a potent, non-toxic anti-cancer agent. | Amino Acids | 2013
Evidence 2 Activity

Activity

% Hemolysis
Toxicity
50 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 50% Hemolysis=11 µM | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Amino Acids. 2013 Feb 44(2):715-23.
Evidence 3 Hemolysis

Source & Reference

HemoPI PD_Hemolysis
PD_Hemolysis