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Peptide record

TPDB21330

Antibacterial Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB21330
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 18-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
IKRQYKRFFKLFKWFLKK
Physicochemical Analysis
C127H194N32O21
ANDCEGHMPSTV
K
2505.14
11.74
8
0
9
+8
-0.60
-0.822
65.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
6990
279.03
2
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
1
Q
0
G
0
H
1
I
2
L
6
K
0
M
4
F
0
P
0
S
0
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 1 L: 2 K: 6 M: 0 F: 4 P: 0 S: 0 T: 0 W: 1 Y: 1 V: 0
Chemical Descriptors
18
C127H194N32O21
2505.14
11.74
+8
-0.60
-0.822
Evidence Records 1 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
25 µM
Hemolytic Cytotoxic
50% Hemolysis | 25 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
The synthetic antimicrobial peptide IKR18 displays anti-infectious properties in galleria mellonella in vivo model. | Biochim Biophys Acta | 2022