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Peptide record

TPDB21299

Antibacterial Anticancer Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB21299
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 9-aa standard-residue multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
IIRWWWRII
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C69H100N18O10
ANDCEQGHLKMFPSTYV
I
1341.67
12.40
2
0
7
+2
0.35
0.700
173.33
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
16500
12.30
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
4
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 4 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
9 reviewed residue count
C69H100N18O10 sequence-only estimate (linear, free termini)
1341.67 sequence-only estimate (linear, free termini)
12.40 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
0.35 sequence-only estimate (linear, free termini)
0.700 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

20% Killing
Toxicity
64 µM
Cytotoxic
20% Killing | 64 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Novel Arginine End-Tagging Antimicrobial Peptides to Combat Multidrug-Resistant Bacteria. | ACS Appl Mater Interfaces | 2022
Evidence 2 Activity

Activity

25% Killing
Toxicity
64 µM
Cytotoxic
25% Killing | 64 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Novel Arginine End-Tagging Antimicrobial Peptides to Combat Multidrug-Resistant Bacteria. | ACS Appl Mater Interfaces | 2022