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Peptide record

TPDB21293

Antibacterial Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB21293
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
IIPLPLKKFLKKL
Physicochemical Analysis
C79H139N17O14
ARNDCEQGHMSTWYV
LK
1551.08
11.00
4
0
7
+4
0.87
0.631
180.00
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
4
L
4
K
0
M
1
F
2
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 4 K: 4 M: 0 F: 1 P: 2 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
13
C79H139N17O14
1551.08
11.00
+4
0.87
0.631
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
25 µM

Target

Escherichia coli

Source & Reference

NA

Other

active against E. coli (MIC 25 uM), P. aeruginosa (MIC 6.25uM), E. aerogenes (MIC 3.13 uM), E.cloacae (MIC > 100 uM), K. pne
Evidence 2 Activity

Activity

MIC
Antibacterial
6.25 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

active against E. coli (MIC 25 uM), P. aeruginosa (MIC 6.25uM), E. aerogenes (MIC 3.13 uM), E.cloacae (MIC > 100 uM), K. pneumoniae (MIC 25 uM), S. aure
Evidence 3 Activity

Activity

MIC
Antibacterial
3.13 µM

Target

Enterobacter aerogenes

Source & Reference

NA

Other

active against E. coli (MIC 25 uM), P. aeruginosa (MIC 6.25uM), E. aerogenes (MIC 3.13 uM), E.cloacae (MIC > 100 uM), K. pneumoniae (MIC 25 uM), S. aureus (MIC 25 uM), B. cereus (M
Evidence 4 Activity

Activity

MIC
Antibacterial
25 µM

Target

Klebsiella pneumoniae

Source & Reference

NA

Other

25 uM), P. aeruginosa (MIC 6.25uM), E. aerogenes (MIC 3.13 uM), E.cloacae (MIC > 100 uM), K. pneumoniae (MIC 25 uM), S. aureus (MIC 25 uM), B. cereus (MIC 1.56 uM), S.lactis (MIC >100 uM), E. faecalis (MIC
Evidence 5 Activity

Activity

MIC
Antibacterial
25 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

6.25uM), E. aerogenes (MIC 3.13 uM), E.cloacae (MIC > 100 uM), K. pneumoniae (MIC 25 uM), S. aureus (MIC 25 uM), B. cereus (MIC 1.56 uM), S.lactis (MIC >100 uM), E. faecalis (MIC 3.13 uM), E. faecium (
Evidence 6 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

B. cereus

Source & Reference

NA

Other

MIC 3.13 uM), E.cloacae (MIC > 100 uM), K. pneumoniae (MIC 25 uM), S. aureus (MIC 25 uM), B. cereus (MIC 1.56 uM), S.lactis (MIC >100 uM), E. faecalis (MIC 3.13 uM), E. faecium (MIC 1.56 uM). Also inhibi
Evidence 7 Activity

Activity

MIC
Antibacterial
>100 µM

Target

S.lactis

Source & Reference

NA

Other

MIC > 100 uM), K. pneumoniae (MIC 25 uM), S. aureus (MIC 25 uM), B. cereus (MIC 1.56 uM), S.lactis (MIC >100 uM), E. faecalis (MIC 3.13 uM), E. faecium (MIC 1.56 uM). Also inhibited biofilm formation:ba
Evidence 8 Activity

Activity

MIC
Antibacterial
3.13 µM

Target

Enterococcus faecalis

Source & Reference

NA

Other

niae (MIC 25 uM), S. aureus (MIC 25 uM), B. cereus (MIC 1.56 uM), S.lactis (MIC >100 uM), E. faecalis (MIC 3.13 uM), E. faecium (MIC 1.56 uM). Also inhibited biofilm formation:bacteria:S. epidermidis.
Evidence 9 Activity

Activity

MIC
Antibacterial
1.56 µM

Target

E. faecium

Source & Reference

NA

Other

(MIC 25 uM), B. cereus (MIC 1.56 uM), S.lactis (MIC >100 uM), E. faecalis (MIC 3.13 uM), E. faecium (MIC 1.56 uM). Also inhibited biofilm formation:bacteria:S. epidermidis.
Evidence 10 Activity

Activity

50% Hemolysis
Toxicity
>500 µM
Hemolytic Cytotoxic
50% Hemolysis | >500 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Membrane mechanism of temporin-1CEc, an antimicrobial peptide isolated from the skin secretions of Rana chensinensis, and its systemic analogs. | Bioorg Chem | 2022