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Peptide record

TPDB21287

Antibacterial Toxicity standard

13 amino acids

3D PDB MODEL

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TPDB ID TPDB21287

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

IILLLLKKFWKKW

FASTA

>TPDB21287|Antibacterial;Toxicity|length=13
IILLLLKKFWKKW

Formula C91H145N19O14

Absent Amino Acids ARNDCEQGHMPSTYV

Common Amino Acids LK

Mass 1729.27

PI 11.00

Basic Residues 4

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +4

Boman Index -3.73

Hydrophobicity 0.738

Aliphatic Index 180.00

Half Life

Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour

Extinction Coefficient Cystines 11000

Absorbance 280nm 636.11

Polar Residues 0

number

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 4 K: 4 M: 0 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0

Length

Formula

C91H145N19O14

Mass

1729.27

11.00

Net Charge

Boman Index

-3.73

Hydrophobicity

0.738

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.13 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli (MIC 3.13 uM), P. aeruginosa (MIC 3.13 uM), E. aerogenes (MIC 1.56 uM), E. cloacae (MIC 1.56 uM), K. pn

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.13 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli (MIC 3.13 uM), P. aeruginosa (MIC 3.13 uM), E. aerogenes (MIC 1.56 uM), E. cloacae (MIC 1.56 uM), K. pneumoniae (MIC 6.25 uM), S. au

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.56 µM

Target

Target Organism Enterobacter aerogenes

Source & Reference

Database Source NA

Other

Evidence Text

active against E. coli (MIC 3.13 uM), P. aeruginosa (MIC 3.13 uM), E. aerogenes (MIC 1.56 uM), E. cloacae (MIC 1.56 uM), K. pneumoniae (MIC 6.25 uM), S. aureus (MIC 0.78 uM), B. cereu

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.56 µM

Target

Target Organism Enterobacter cloacae

Source & Reference

Database Source NA

Other

Evidence Text

e against E. coli (MIC 3.13 uM), P. aeruginosa (MIC 3.13 uM), E. aerogenes (MIC 1.56 uM), E. cloacae (MIC 1.56 uM), K. pneumoniae (MIC 6.25 uM), S. aureus (MIC 0.78 uM), B. cereus (MIC 0.78 uM), S. lactis

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µM

Target

Target Organism Klebsiella pneumoniae

Source & Reference

Database Source NA

Other

Evidence Text

3 uM), P. aeruginosa (MIC 3.13 uM), E. aerogenes (MIC 1.56 uM), E. cloacae (MIC 1.56 uM), K. pneumoniae (MIC 6.25 uM), S. aureus (MIC 0.78 uM), B. cereus (MIC 0.78 uM), S. lactis (MIC 1.56 uM), E. faecalis (

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.78 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

3 uM), E. aerogenes (MIC 1.56 uM), E. cloacae (MIC 1.56 uM), K. pneumoniae (MIC 6.25 uM), S. aureus (MIC 0.78 uM), B. cereus (MIC 0.78 uM), S. lactis (MIC 1.56 uM), E. faecalis (MIC 3.13 uM), E. faecium

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 0.78 µM

Target

Target Organism B. cereus

Source & Reference

Database Source NA

Other

Evidence Text

1.56 uM), E. cloacae (MIC 1.56 uM), K. pneumoniae (MIC 6.25 uM), S. aureus (MIC 0.78 uM), B. cereus (MIC 0.78 uM), S. lactis (MIC 1.56 uM), E. faecalis (MIC 3.13 uM), E. faecium (MIC 6.25 uM).

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.56 µM

Target

Target Organism S. lactis

Source & Reference

Database Source NA

Other

Evidence Text

1.56 uM), K. pneumoniae (MIC 6.25 uM), S. aureus (MIC 0.78 uM), B. cereus (MIC 0.78 uM), S. lactis (MIC 1.56 uM), E. faecalis (MIC 3.13 uM), E. faecium (MIC 6.25 uM).

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.13 µM

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source NA

Other

Evidence Text

(MIC 6.25 uM), S. aureus (MIC 0.78 uM), B. cereus (MIC 0.78 uM), S. lactis (MIC 1.56 uM), E. faecalis (MIC 3.13 uM), E. faecium (MIC 6.25 uM).

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 6.25 µM

Target

Target Organism E. faecium

Source & Reference

Database Source NA

Other

Evidence Text

IC 0.78 uM), B. cereus (MIC 0.78 uM), S. lactis (MIC 1.56 uM), E. faecalis (MIC 3.13 uM), E. faecium (MIC 6.25 uM).

Evidence 11 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 25 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 25 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Membrane mechanism of temporin-1CEc, an antimicrobial peptide isolated from the skin secretions of Rana chensinensis, and its systemic analogs. | Bioorg Chem | 2022