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Peptide record

TPDB21224

Antibacterial Anticancer Antiviral Toxicity modified_plain modified
24 amino acids
Basic Information
3D PDB MODEL
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TPDB21224
Antibacterial Anticancer Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia DRAVP 2.0
modified_plain
Yes
A 24-aa modified multi-activity (Antibacterial, Anticancer, Antiviral, and other sources) peptide sequence curated from Peptipedia and DRAVP 2.0, with an available 3D structural model.
Modified, details unspecified
Sequence
IEELLKKAEEQQKKNEEELKKLEX
Physicochemical Analysis
C123H212N32O43
RDCGHMFPSTWYV
E
2827.22
4.73
6
8
6
-2
20.96
-1.683
85.42
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
3
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
8
E
2
Q
0
G
0
H
1
I
4
L
6
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 8 Q: 2 G: 0 H: 0 I: 1 L: 4 K: 6 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
24
C123H212N32O43
2827.22
4.73
-2
20.96
-1.683
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Cytotoxicity
Toxicity
208.43±22.9 µM
Cytotoxic
50% Cytotoxicity | 208.43±22.9 | µM | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Structural and Functional Characterization of Membrane Fusion Inhibitors With Extremely Potent Activity Against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus. | J Virol | 2018
Evidence 2 Activity

Activity

50% Cytotoxicity
Toxicity
49.95±2.97 µM
Cytotoxic
50% Cytotoxicity | 49.95±2.97 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Structural and Functional Characterization of Membrane Fusion Inhibitors With Extremely Potent Activity Against Human Immunodeficiency Virus Type 1 (HIV-1), HIV-2, and Simian Immunodeficiency Virus. | J Virol | 2018
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
Cytotoxicity: [Ref.30089693]TZM-bl cell:CC50=256.23 ±14.58 µM ##MT-4 cell:CC50=213.4±59.59 µM ##HEK293T cell:CC50=208.43± 22.9µM ##PBMC:CC50=49.95± 2.97 µM.

Source & Reference

NA
DRAMP
J Virol. 2018 Sep 26 92(20):e01088-18.