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Peptide record

TPDB21220

Antibacterial Anticancer Antiviral Toxicity modified_plain modified
37 amino acids
Basic Information
3D PDB MODEL
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TPDB21220
Antibacterial Anticancer Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia dbAMP 3.0
modified_plain
Yes
A 37-aa modified multi-activity (Antibacterial, Anticancer, Antiviral, and other sources) peptide sequence curated from Peptipedia and dbAMP 3.0, with an available 3D structural model.
Modified, details unspecified
Sequence
IEEIYKKIEEIYKKIEEIYKKIEEIYKKIEEIYKKXK
Physicochemical Analysis
C221H359N47O62
ARNDCQGHLMFPSTWV
K
4666.56
9.05
11
10
15
+1
23.29
-1.065
105.41
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
7450
159.65
5
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
10
E
0
Q
0
G
0
H
10
I
0
L
11
K
0
M
0
F
0
P
0
S
0
T
0
W
5
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 10 Q: 0 G: 0 H: 0 I: 10 L: 0 K: 11 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 5 V: 0
Chemical Descriptors
37
C221H359N47O62
4666.56
9.05
+1
23.29
-1.065
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Cytotoxicity
Toxicity
>100 µM
Cytotoxic
50% Cytotoxicity | >100 | µM | target cell: Madin-Darby canine kidney cells

Target

Madin-Darby canine kidney cells

Source & Reference

NA
DBAASP
De Novo Design of alpha-Helical Lipopeptides Targeting Viral Fusion Proteins: A Promising Strategy for Relatively Broad-Spectrum Antiviral Drug Discovery. | J Med Chem | 2018
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
J Med Chem. 2018 Oct 11 61(19):8734-8745.