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Peptide record

TPDB21193

Antibacterial Anticancer Toxicity modified_plain modified
14 amino acids
Basic Information
3D PDB MODEL
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TPDB21193
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 14-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
IDWKKLLDAAKQIX
Physicochemical Analysis
C72H120N18O19
RNCEGHMFPSTYV
K
1541.85
9.76
3
2
7
+1
2.08
-0.207
125.71
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
356.71
1
Residue Composition
number
2
A
0
R
0
N
2
D
0
C
0
E
1
Q
0
G
0
H
2
I
2
L
3
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 2 C: 0 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 2 K: 3 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
14
C72H120N18O19
1541.85
9.76
+1
2.08
-0.207
Evidence Records 2 records
Evidence 1 Activity

Activity

50% Cell death
Toxicity
>60 µM
Cytotoxic
50% Cell death | >60 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
A novel analog of antimicrobial peptide Polybia-MPI, with thioamide bond substitution, exhibits increased therapeutic efficacy against cancer and diminished toxicity in mice. | Peptides | 2010
Evidence 2 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: NIH 3T3: 50% Cell death>60 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2010 Oct 31(10):1832-8.