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Peptide record

TPDB21190

Antibacterial Antifungal Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB21190
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia and CAFPdb, with an available 3D structural model.
Sequence
IDWHHLLDAAHQIL
Physicochemical Analysis
C78H116N22O20
RNCEGKMFPSTYV
HL
1681.91
5.72
3
2
8
-2
1.43
0.214
153.57
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
5500
327.01
1
Residue Composition
number
2
A
0
R
0
N
2
D
0
C
0
E
1
Q
0
G
3
H
2
I
3
L
0
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 2 C: 0 E: 0 Q: 1 G: 0 H: 3 I: 2 L: 3 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
14
C78H116N22O20
1681.91
5.72
-2
1.43
0.214
Evidence Records 3 records
Evidence 1 Activity

Activity

32% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
32% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cu2+ reduces hemolytic activity of the antimicrobial peptide HMPI and enhances its trypsin resistance. | Acta Biochim Biophys Sin | 2020
Evidence 2 Activity

Activity

<5% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
<5% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cu2+ reduces hemolytic activity of the antimicrobial peptide HMPI and enhances its trypsin resistance. | Acta Biochim Biophys Sin | 2020
Evidence 3 Activity

Activity

10% Inhibition
Toxicity
125 µM
Cytotoxic
10% Inhibition | 125 | µM | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Cu2+ reduces hemolytic activity of the antimicrobial peptide HMPI and enhances its trypsin resistance. | Acta Biochim Biophys Sin | 2020