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Peptide record

TPDB21171

Antibacterial Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB21171
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 18-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
HVFRLKKWIQKVIDQFGE
Physicochemical Analysis
C108H167N29O25
ANCMPSTY
K
2271.69
10.31
5
2
8
+2
4.01
-0.439
97.22
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
5500
242.11
2
Residue Composition
number
0
A
1
R
0
N
1
D
0
C
1
E
2
Q
1
G
1
H
2
I
1
L
3
K
0
M
2
F
0
P
0
S
0
T
1
W
0
Y
2
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 0 E: 1 Q: 2 G: 1 H: 1 I: 2 L: 1 K: 3 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 2
Chemical Descriptors
18
C108H167N29O25
2271.69
10.31
+2
4.01
-0.439
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

zone inhibition: active against E. coli, P. aeruginosa, S. aureus, and C. albicans.
Evidence 2 Activity

Activity

8.7% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
8.7% Hemolysis | 200 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Thrombin-Derived Peptides Potentiate the Activity of Gram-Positive-Specific Antibiotics against Gram-Negative Bacteria. | Molecules | 2021