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Peptide record

TPDB21167

ACE inhibitor from kappa-CN (fr. 22-24) Hypotensive peptide ACE inhibitors Antibacterial Antihypertensive standard
3 amino acids
Basic Information
3D PDB MODEL
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TPDB21167
ACE inhibitor from kappa-CN (fr. 22-24) Hypotensive peptide
ACE inhibitors Antibacterial Antihypertensive
Anti-infective peptides Cardiometabolic peptides
Peptipedia AHTPDB AHTpin
standard
No
A 3-aa standard natural multi-activity (ACE inhibitors, Antibacterial, and Antihypertensive) peptide sequence curated from Peptipedia, AHTPDB, and AHTpin, with an available 3D structural model.
Sequence
IAK
Physicochemical Analysis
C15H30N4O4
RNDCEQGHLMFPSTWYV
AIK
330.43
10.10
1
0
2
+1
0.51
0.800
163.33
Mammalian: 20 hour Yeast: 30 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
1
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
1
I
0
L
1
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 1 L: 0 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
3
C15H30N4O4
330.43
10.10
+1
0.51
0.800
330.4219
330.2260
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
15.70 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Gómez-Ruiz J. A., Ramos M., Recio I.
Identification of novel angiotensin-converting enzyme-inhibitory peptides from ovine milk proteins by CE-MS and chromatographic techniques. Electrophoresis, 28, 4202-4211, 2007
2007
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C15H30N4O4/c1-4-9(2)12(17)14(21)18-10(3)13(20)19-11(15(22)23)7-5-6-8-16/h9-12H,4-8,16-17H2,1-3H3,(H,18,21)(H,19,20)(H,22,23)/t9-,10-,11-,12-/m0/s1 InChIKey=RWIKBYVJQAJYDP-BJDJZHNGSA-N Antibacterial peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10105) the EROP-Moscow database the MBPDB database Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10106) the MBPDB database
Evidence 2 Activity

Activity

IC50
Antihypertensive
15.70 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Gómez-Ruiz J. A., Ramos M., Recio I.
Identification of novel angiotensin-converting enzyme-inhibitory peptides from ovine milk proteins by CE-MS and chromatographic techniques. Electrophoresis, 28, 4202-4211, 2007
2007
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C15H30N4O4/c1-4-9(2)12(17)14(21)18-10(3)13(20)19-11(15(22)23)7-5-6-8-16/h9-12H,4-8,16-17H2,1-3H3,(H,18,21)(H,19,20)(H,22,23)/t9-,10-,11-,12-/m0/s1 InChIKey=RWIKBYVJQAJYDP-BJDJZHNGSA-N Antibacterial peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10105) the EROP-Moscow database the MBPDB database Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10106) the MBPDB database
Evidence 3 Activity

Activity

EC50
Antihypertensive
0.00 µM
Lowering blood pressure in rats
hypotensive
hyp

Source & Reference

AHTPDB
Miguel M., Gómez-Ruiz J. A., Recio I., Aleixandre A.
Changes in arterial blood pressure after single oral administration of milk-casein-derived peptides in spontaneously hypertensive rats. Mol. Nutr. Food Res., 54, 1422-1427, 2010
2010
Journal

Other

3
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])([C@]([H])(CC)C)C(=O)N[C@@]([H])(C)C(=O)N[C@@]([H])(CCCCN)C(=O)O InChI=1S/C15H30N4O4/c1-4-9(2)12(17)14(21)18-10(3)13(20)19-11(15(22)23)7-5-6-8-16/h9-12H,4-8,16-17H2,1-3H3,(H,18,21)(H,19,20)(H,22,23)/t9-,10-,11-,12-/m0/s1 InChIKey=RWIKBYVJQAJYDP-BJDJZHNGSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BIOPEP-UWM database of bioactive peptides (ID 7626) the EROP-Moscow database the MBPDB database Hypotensive peptide according to the BIOPEP-UWM database of bioactive peptides (ID 10106) the MBPDB database
Additional Detail Fields 1 fields
3