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Peptide record

TPDB21162

ACE inhibitor from sake Anti-inflammatory peptide dipeptidyl peptidase IV inhibitor (DPP IV inhibitor) ACE inhibitors Anti-inflammatory Antibacterial Anticancer Antifungal Antihypertensive Neuropeptide iDPPIV standard
2 amino acids
Basic Information
3D PDB MODEL
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TPDB21162
ACE inhibitor from sake Anti-inflammatory peptide dipeptidyl peptidase IV inhibitor (DPP IV inhibitor)
ACE inhibitors Anti-inflammatory Antibacterial Anticancer Antifungal Antihypertensive Neuropeptide iDPPIV
Anti-infective peptides Cardiometabolic peptides Cancer-related peptides Immunity and inflammation peptides Neuroactive peptides
Peptipedia AHTPDB AHTpin iDPPIV
standard
No
A 2-aa standard natural multi-activity (ACE inhibitors, Anti-inflammatory, Antibacterial, and other sources) peptide sequence curated from Peptipedia, AHTPDB, AHTpin, and other sources, with an available 3D structural model.
Sequence
HY
Physicochemical Analysis
C15H18N4O4
ARNDCEQGILKMFPSTWV
HY
318.33
7.77
1
0
1
+0
0.02
-2.250
0.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
1490
468.06
1
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
1
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 1 V: 0
Chemical Descriptors
2
C15H18N4O4
318.33
7.77
+0
0.02
-2.250
318.3271
318.1324
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
ACE inhibitors
26.10 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

NA
Saito Y., Wanezaki K., Kawato A., Imayasu S.
Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci. Biotech. Biochem., 58 (10), 1767-1771 (1994)
1994
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[N]([H])C=N1)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)O InChI=1S/C15H18N4O4/c16-12(6-10-7-17-8-18-10)14(21)19-13(15(22)23)5-9-1-3-11(20)4-2-9/h1-4,7-8,12-13,20H,5-6,16H2,(H,17,18)(H,19,21)(H,22,23)/t12-,13-/m0/s1 InChIKey=HTOOKGDPMXSJSY-STQMWFEESA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Peptide found in amaranth (Amarantus hypochondriacus) protein hydrolysate: Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8799) Anti-inflammatory peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9869)
Evidence 2 Activity

Activity

EC50
Anti-inflammatory
0.00 µM
Anti-inflammatory
anti inflammatory
ai

Source & Reference

NA
Wang S., Zheng L., Zhao T., Zhang Q., Liu Y., Sun B., Su G., Zhao M.
Inhibitory effects of walnut (Juglans regia) peptides on neuroinflammation and oxidative stress in lipopolysaccharide-induced cognitive impairment mice. J. Agric. Food Chem., 68, 2381-2392, 2020
2020
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)O InChI=1S/C15H27N5O6/c1-7(2)5-10(20-13(23)8(16)6-12(18)22)14(24)19-9(15(25)26)3-4-11(17)21/h7-10H,3-6,16H2,1-2H3,(H2,17,21)(H2,18,22)(H,19,24)(H,20,23)(H,25,26)/t8-,9-,10-/m0/s1 InChIKey=HFPXZWPUVFVNLL-GUBZILKMSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BindingDB database the BIOPEP-UWM database of bioactive peptides (ID 3494) the ChEMBL database the EROP-Moscow database the PubChem database Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8799)
Evidence 3 Activity

Activity

IC50
Antihypertensive
26.10 µM
Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001)
ACE inhibitor
ah

Source & Reference

AHTPDB
Saito Y., Wanezaki K., Kawato A., Imayasu S.
Structure and activity of angiotensin I converting enzyme inhibitory peptides from sake and sake lees. Biosci. Biotech. Biochem., 58 (10), 1767-1771 (1994)
1994
Journal

Other

Source Activity Label Source Definition
Antihypertensive
AHTPDB manually curated experimentally validated antihypertensive peptide annotation.
2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@H](CC1=C[N]([H])C=N1)C(=O)N[C@@H](CC2=CC=C(C=C2)O)C(=O)O InChI=1S/C15H18N4O4/c16-12(6-10-7-17-8-18-10)14(21)19-13(15(22)23)5-9-1-3-11(20)4-2-9/h1-4,7-8,12-13,20H,5-6,16H2,(H,17,18)(H,19,21)(H,22,23)/t12-,13-/m0/s1 InChIKey=HTOOKGDPMXSJSY-STQMWFEESA-N Information concerning Angiotensin-Converting Enzyme (ACE) is available in MEROPS database of proteolytic enzymes (http://merops.sanger.ac.uk/) ID: M02-001 Peptide found in amaranth (Amarantus hypochondriacus) protein hydrolysate: Barba de la Rosa A. P., Barba Montoya A., Martínez-Cuevas P., Hernández-Ledesma B., León-Galván M. F., De León-Rodríguez A., González C., 2010, Tryptic amaranth glutelin digests induce endothelial nitric oxide production through inhibition of ACE: antihypertensive role of amaranth peptides. Nitric Oxide, 23, 106-111 Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003) according to the BIOPEP-UWM database of bioactive peptides (ID 8799) Anti-inflammatory peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9869)
Evidence 4 Activity

Activity

IC50
iDPPIV
0.00 µM
Inhibitor of Dipeptidyl Peptidase IV (EC 3.4.14.5) (MEROPS ID: S09.003)
dipeptidyl peptidase IV inhibitor
dpp

Source & Reference

iDPPIV
Lan V. T. T., Ito K., Ohno M., Motoyama T., Ito S., Kawarasaki Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor. Food Chemistry 175, 66-73, 2015
2015
Journal

Other

2
BIOPEP-UWM database of bioactive peptides SMILES: N[C@@]([H])(CC(=O)N)C(=O)N[C@@]([H])(CC(C)C)C(=O)N[C@@]([H])(CCC(=O)N)C(=O)O InChI=1S/C15H27N5O6/c1-7(2)5-10(20-13(23)8(16)6-12(18)22)14(24)19-9(15(25)26)3-4-11(17)21/h7-10H,3-6,16H2,1-2H3,(H2,17,21)(H2,18,22)(H,19,24)(H,20,23)(H,25,26)/t8-,9-,10-/m0/s1 InChIKey=HFPXZWPUVFVNLL-GUBZILKMSA-N Inhibitor of Angiotensin-Converting Enzyme (ACE) (EC 3.4.15.1) (MEROPS ID: M02-001) according to the AHTPDB database the BindingDB database the BIOPEP-UWM database of bioactive peptides (ID 3494) the ChEMBL database the EROP-Moscow database the PubChem database Anti-inflammatory peptide according to the BIOPEP-UWM database of bioactive peptides (ID 9869)
Additional Detail Fields 1 fields
2