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Peptide record

TPDB21156

Antibacterial Antifungal standard
71 amino acids
Basic Information
3D PDB MODEL
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TPDB21156
Antibacterial Antifungal
Anti-infective peptides
Peptipedia AFP-GFuse Antifungipept CAFPdb DRAMP dbAMP
standard
No
A 71-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia, AFP-GFuse, Antifungipept, and other sources, with an available 3D structural model.
Sequence
HTPTPTPICKSRSHEYKGRCIQDMDCNAACVKESESYTGGFCNGRPPFKQCFCTKPCKRERAAATLRWPGL
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C340H534N104O100S9
C
7967.16
8.73
14
6
17
+6
2.38
-0.786
33.10
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
8980
1.13
24
Residue Composition
number
5
A
6
R
2
N
2
D
8
C
4
E
2
Q
5
G
2
H
2
I
2
L
6
K
1
M
3
F
7
P
4
S
6
T
1
W
2
Y
1
V
Amino Acid Distribution
A: 5 R: 6 N: 2 D: 2 C: 8 E: 4 Q: 2 G: 5 H: 2 I: 2 L: 2 K: 6 M: 1 F: 3 P: 7 S: 4 T: 6 W: 1 Y: 2 V: 1
Chemical Descriptors
71 reviewed residue count
C340H534N104O100S9 sequence-only estimate (linear, free termini)
7967.16 sequence-only estimate (linear, free termini)
8.73 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
2.38 sequence-only estimate (linear, free termini)
-0.786 sequence-only estimate (linear, free termini)
Evidence Records 4 records
Evidence 1 Activity

Activity

IC50
Antibacterial
15 µM

Target

N. crassa

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
DRAMP antibacterial activity supported by MIC records against bacterial target organisms. dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active (IC50: 50% growth inhibition) against fungi such as N. crassa (IC50 15 uM), A-niger (IC50 >20 uM), and F. solani (IC50 10 uM). (50% inhibition concentration IC50 =
Evidence 2 Activity

Activity

IC50
Antibacterial
10 µM

Target

F. solani

Source & Reference

dbAMP DRAMP

Other

owth inhibition) against fungi such as N. crassa (IC50 15 uM), A-niger (IC50 >20 uM), and F. solani (IC50 10 uM). (50% inhibition concentration IC50 = 10-15 uM).
Evidence 3 Activity

Activity

IC50
Antifungal
15 µM

Target

N. crassa

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

Source Activity Label Source Definition
Antifungal
DRAMP antifungal activity supported by activity records against fungal target organisms. dbAMP classified under the Anti-fungal function class.
Active (IC50: 50% growth inhibition) against fungi such as N. crassa (IC50 15 uM), A-niger (IC50 >20 uM), and F. solani (IC50 10 uM). (50% inhibition concentration IC50 =
Evidence 4 Activity

Activity

IC50
Antifungal
10 µM

Target

F. solani

Source & Reference

dbAMP DRAMP CAFPdb Antifungipept

Other

owth inhibition) against fungi such as N. crassa (IC50 15 uM), A-niger (IC50 >20 uM), and F. solani (IC50 10 uM). (50% inhibition concentration IC50 = 10-15 uM).