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Peptide record

TPDB21138

Pituitary adenylate cyclase-activating polypeptide 38 Antibacterial Antifungal Blood-Brain Barrier Cell-penetrating Peptides Neuropeptide Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB21138
Pituitary adenylate cyclase-activating polypeptide 38
Antibacterial Antifungal Blood-Brain Barrier Cell-penetrating Peptides Neuropeptide Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides Neuroactive peptides
Peptipedia AFP-GFuse CAFPdb BBPpredict CellPPD-MOD CPPsite3.0 MLCPP 2.0
standard
No
A 38-aa standard natural multi-activity (Antibacterial, Antifungal, Blood-Brain Barrier, and other sources) peptide sequence curated from Peptipedia, AFP-GFuse, CAFPdb, and other sources, with an available 3D structural model.
Sequence
HSDGIFTDSYSRYRKQMAVKKYLAAVLGKRYKQRVKNK
Physicochemical Analysis
C203H330N62O54S1
CEPW
K
4535.30
10.79
12
2
15
+9
8.87
-1.061
61.58
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
5960
131.41
11
Residue Composition
number
3
A
4
R
1
N
2
D
0
C
0
E
2
Q
2
G
1
H
1
I
2
L
7
K
1
M
1
F
0
P
3
S
1
T
0
W
4
Y
3
V
Amino Acid Distribution
A: 3 R: 4 N: 1 D: 2 C: 0 E: 0 Q: 2 G: 2 H: 1 I: 1 L: 2 K: 7 M: 1 F: 1 P: 0 S: 3 T: 1 W: 0 Y: 4 V: 3
Chemical Descriptors
38
C203H330N62O54S1
4535.30
10.79
+9
8.87
-1.061
Evidence Records 19 records
Evidence 1 Activity

Activity

MIC
Antibacterial
28.3 µM

Target

Escherichia coli

Source & Reference

NA

Other

Active against E. coli (MIC 28.3 uM), S.aureus (MIC >30 uM), P. aeruginosa (MIC 1.2 uM), and B. cereus (MIC 23.3) (see ref). A
Evidence 2 Activity

Activity

MIC
Antibacterial
>30 µM

Target

S.aureus

Source & Reference

NA

Other

Active against E. coli (MIC 28.3 uM), S.aureus (MIC >30 uM), P. aeruginosa (MIC 1.2 uM), and B. cereus (MIC 23.3) (see ref). Another study (PMID:3046
Evidence 3 Activity

Activity

MIC
Antibacterial
1.2 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

Active against E. coli (MIC 28.3 uM), S.aureus (MIC >30 uM), P. aeruginosa (MIC 1.2 uM), and B. cereus (MIC 23.3) (see ref). Another study (PMID:30462698): Active against B. cen
Evidence 4 Activity

Activity

MIC
Antibacterial
7.5 µg/mL

Target

A. pleuropneumoniae

Source & Reference

NA

Other

ef). Another study (PMID:30462698): Active against B. cenocepacia (J2315) (MIC 10 ug/ml), A. pleuropneumoniae (MIC 7.5 ug/ml), B. subtilis (PY79) (MIC 28 ug/ml), B. velezensis (MIC 76 ug/ml), B. amyloliquefaciens (M
Evidence 5 Activity

Activity

MIC
Antibacterial
76 µg/mL

Target

B. velezensis

Source & Reference

NA

Other

) (MIC 10 ug/ml), A. pleuropneumoniae (MIC 7.5 ug/ml), B. subtilis (PY79) (MIC 28 ug/ml), B. velezensis (MIC 76 ug/ml), B. amyloliquefaciens (MIC 42 ug/ml), inactive against P.putida (KT2440) (MIC 113 ug/ml),
Evidence 6 Activity

Activity

MIC
Antibacterial
42 µg/mL

Target

B. amyloliquefaciens

Source & Reference

NA

Other

umoniae (MIC 7.5 ug/ml), B. subtilis (PY79) (MIC 28 ug/ml), B. velezensis (MIC 76 ug/ml), B. amyloliquefaciens (MIC 42 ug/ml), inactive against P.putida (KT2440) (MIC 113 ug/ml), P.fluorescens (MF37), E.coli (JM109)
Evidence 7 Activity

Activity

MIC
Antifungal
28.3 µM

Target

Escherichia coli

Source & Reference

CAFPdb

Other

Active against E. coli (MIC 28.3 uM), S.aureus (MIC >30 uM), P. aeruginosa (MIC 1.2 uM), and B. cereus (MIC 23.3) (see ref). A
Evidence 8 Activity

Activity

MIC
Antifungal
>30 µM

Target

S.aureus

Source & Reference

CAFPdb

Other

Active against E. coli (MIC 28.3 uM), S.aureus (MIC >30 uM), P. aeruginosa (MIC 1.2 uM), and B. cereus (MIC 23.3) (see ref). Another study (PMID:3046
Evidence 9 Activity

Activity

MIC
Antifungal
1.2 µM

Target

Pseudomonas aeruginosa

Source & Reference

CAFPdb

Other

Active against E. coli (MIC 28.3 uM), S.aureus (MIC >30 uM), P. aeruginosa (MIC 1.2 uM), and B. cereus (MIC 23.3) (see ref). Another study (PMID:30462698): Active against B. cen
Evidence 10 Activity

Activity

MIC
Antifungal
7.5 µg/mL

Target

A. pleuropneumoniae

Source & Reference

CAFPdb

Other

ef). Another study (PMID:30462698): Active against B. cenocepacia (J2315) (MIC 10 ug/ml), A. pleuropneumoniae (MIC 7.5 ug/ml), B. subtilis (PY79) (MIC 28 ug/ml), B. velezensis (MIC 76 ug/ml), B. amyloliquefaciens (M
Evidence 11 Activity

Activity

MIC
Antifungal
76 µg/mL

Target

B. velezensis

Source & Reference

CAFPdb

Other

) (MIC 10 ug/ml), A. pleuropneumoniae (MIC 7.5 ug/ml), B. subtilis (PY79) (MIC 28 ug/ml), B. velezensis (MIC 76 ug/ml), B. amyloliquefaciens (MIC 42 ug/ml), inactive against P.putida (KT2440) (MIC 113 ug/ml),
Evidence 12 Activity

Activity

MIC
Antifungal
42 µg/mL

Target

B. amyloliquefaciens

Source & Reference

CAFPdb

Other

umoniae (MIC 7.5 ug/ml), B. subtilis (PY79) (MIC 28 ug/ml), B. velezensis (MIC 76 ug/ml), B. amyloliquefaciens (MIC 42 ug/ml), inactive against P.putida (KT2440) (MIC 113 ug/ml), P.fluorescens (MF37), E.coli (JM109)
Evidence 13 Activity

Activity

Neuropeptide

Target

Pituitary adenylate cyclase-activating polypeptide type I receptor
Bos taurus

Source & Reference

NA
NeuroPepV2

Other

Bos taurus
Glucagon
513
NP04401 NP04415 NP04424 NP04450 NP04376 NP04463
Evidence 14 Activity

Activity

Neuropeptide

Target

Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal polypeptide receptor 2 Pituitary adenylate cyclase-activating polypeptide type I receptor
Homo sapiens Homo sapiens Homo sapiens

Source & Reference

NA
NeuroPepV2

Other

Homo sapiens
Glucagon
457 438 468
NP04418 NP04427 NP04470 NP04418 NP04427 NP04470 NP04418 NP04427
Evidence 15 Activity

Activity

Neuropeptide

Target

Pituitary adenylate cyclase-activating polypeptide type I receptor Vasoactive intestinal polypeptide receptor 2
Mus musculus Mus musculus

Source & Reference

NA
NeuroPepV2

Other

Mus musculus
Glucagon
496 437
NP04419 NP04428 NP04419 NP04428 NP04473
Evidence 16 Activity

Activity

Neuropeptide

Source & Reference

NA
NeuroPepV2

Other

Sus scrofa
Glucagon
Evidence 17 Activity

Activity

Neuropeptide

Target

Pituitary adenylate cyclase-activating polypeptide type I receptor Vasoactive intestinal polypeptide receptor 2
Rattus norvegicus Rattus norvegicus

Source & Reference

NA
NeuroPepV2

Other

Rattus norvegicus
Glucagon
523 437
NP04422 NP04431 NP04422 NP04431 NP04478
Evidence 18 Activity

Activity

Neuropeptide

Source & Reference

NA
NeuroPepV2

Other

Ovis aries
Glucagon
Evidence 19 Activity

Activity

<10% Hemolysis
Toxicity
30 µM
Hemolytic Cytotoxic
<10% Hemolysis | 30 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Pituitary adenylate cyclase-activating polypeptide is a potent broad-spectrum antimicrobial peptide: Structure-activity relationships. | Peptides | 2018
Additional Detail Fields 3 fields
Glucagon
513 457 438 468 496 437 523
NP04401 NP04415 NP04424 NP04450 NP04376 NP04463 NP04418 NP04427 NP04470 NP04419 NP04428 NP04473 NP04422 NP04431 NP04478