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Peptide record

TPDB21134

Antibacterial Antifungal Antiparasitic Toxicity standard
26 amino acids
Basic Information
3D PDB MODEL
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TPDB21134
Antibacterial Antifungal Antiparasitic Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia Antifungipept dbAMP 3.0 ToxinPred 3.0
standard
No
A 26-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from Peptipedia, Antifungipept, dbAMP 3.0, and other sources, with an available 3D structural model.
Sequence
HRRQGPIFDTRPSPFNPNQPRPGPIY
Physicochemical Analysis
C137H206N44O36
ACELKMWV
P
3045.42
11.93
5
1
5
+3
7.05
-1.496
30.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
1490
48.93
7
Residue Composition
number
0
A
4
R
2
N
1
D
0
C
0
E
2
Q
2
G
1
H
2
I
0
L
0
K
0
M
2
F
7
P
1
S
1
T
0
W
1
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 2 D: 1 C: 0 E: 0 Q: 2 G: 2 H: 1 I: 2 L: 0 K: 0 M: 0 F: 2 P: 7 S: 1 T: 1 W: 0 Y: 1 V: 0
Chemical Descriptors
26
C137H206N44O36
3045.42
11.93
+3
7.05
-1.496
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

It exhibited significant (P Tonk et al. 2019 ). Updated 7/2021
Evidence 2 Activity

Activity

Antifungal

Source & Reference

Antifungipept

Other

It exhibited significant (P Tonk et al. 2019 ). Updated 7/2021
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
It exhibited significant (P Tonk et al. 2019 ). Updated 7/2021
Evidence 4 Activity

Activity

<10% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
<10% Hemolysis | 100 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
The Drosophila melanogaster antimicrobial peptides Mtk-1 and Mtk-2 are active against the malarial parasite Plasmodium falciparum. | Parasitol Res | 2019
Evidence 5 Activity

Activity

10% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
10% Hemolysis | 100 | µM | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
The Drosophila melanogaster antimicrobial peptides Mtk-1 and Mtk-2 are active against the malarial parasite Plasmodium falciparum. | Parasitol Res | 2019