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Peptide record

TPDB21126

Antibacterial Anticancer Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB21126
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
HRIRQLKTTIKKFWEIWPKI
Physicochemical Analysis
C126H201N35O26
ANDCGMSYV
IK
2622.20
11.63
7
1
8
+5
3.24
-0.750
97.50
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
11000
419.49
3
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
1
E
1
Q
0
G
1
H
4
I
1
L
4
K
0
M
1
F
1
P
0
S
2
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 1 Q: 1 G: 0 H: 1 I: 4 L: 1 K: 4 M: 0 F: 1 P: 1 S: 0 T: 2 W: 2 Y: 0 V: 0
Chemical Descriptors
20
C126H201N35O26
2622.20
11.63
+5
3.24
-0.750
Evidence Records 3 records
Evidence 1 Activity

Activity

EC50
Toxicity
58.1±0.3 µM
Cytotoxic
EC50 | 58.1±0.3 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
50% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 3 Activity

Activity

HC50
Toxicity
200 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50>200 µM | Cytotoxicity: HDMEC: EC50=58.1 ± 0.3 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2019 Aug 2 9(1):11282.