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Peptide record

TPDB21114

linear (HR)2 Antibacterial Cell-penetrating Peptides standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB21114
linear (HR)2
Antibacterial Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
Peptipedia CPPsite3.0
standard
No
A 4-aa standard natural multi-activity (Antibacterial and Cell-penetrating Peptides) peptide sequence curated from Peptipedia and CPPsite3.0, with an available 3D structural model.
Chemical: Arachidic acid (C20)
Sequence
HRHR
Physicochemical Analysis
C24H40N14O5
ANDCEQGILKMFPSTWYV
RH
604.67
12.40
4
0
0
+2
3.54
-3.850
0.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
0
0.00
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
2
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 2 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C24H40N14O5
604.67
12.40
+2
3.54
-3.850
Free
Arachidic acid (C20)
L
Cationic
Linear
Free
N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](Cc1[nH]cnc1)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Sk-Ov-3 And CCRF-CEM Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
CF-labelled GpYEEI
The C20-(HR)2 peptide did not mediate the cellular uptake of CF-GpYEEI
In vitro
CCCCC
Additional Detail Fields 1 fields
CCCCC