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Peptide record

TPDB21069

Antibacterial Antifungal Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB21069
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb
standard
No
A 10-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia and CAFPdb, with an available 3D structural model.
Sequence
HKVTMTCSAS
Physicochemical Analysis
C42H73N13O15S2
RNDEQGILFPWY
ST
1064.24
8.97
2
0
3
+1
1.92
0.030
39.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
0
0.00
5
Residue Composition
number
1
A
0
R
0
N
0
D
1
C
0
E
0
Q
0
G
1
H
0
I
0
L
1
K
1
M
0
F
0
P
2
S
2
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 0 D: 0 C: 1 E: 0 Q: 0 G: 0 H: 1 I: 0 L: 0 K: 1 M: 1 F: 0 P: 0 S: 2 T: 2 W: 0 Y: 0 V: 1
Chemical Descriptors
10
C42H73N13O15S2
1064.24
8.97
+1
1.92
0.030
Evidence Records 4 records
Evidence 1 Activity

Activity

<2% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
<2% Hemolysis | 50 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In Vitro and In Vivo Anti- Candida Activity and Structural Analysis of Killer Peptide (KP)-Derivatives. | J Fungi (Basel) | 2021
Evidence 2 Activity

Activity

3.23% Killing
Toxicity
10 µM
Cytotoxic
3.23% Killing | 10 | µM | target cell: Monkey kidney epithelial cells LLC-MK2

Target

Monkey kidney epithelial cells LLC-MK2

Source & Reference

NA
DBAASP
In Vitro and In Vivo Anti- Candida Activity and Structural Analysis of Killer Peptide (KP)-Derivatives. | J Fungi (Basel) | 2021
Evidence 3 Activity

Activity

5.1% Killing
Toxicity
25 µM
Cytotoxic
5.1% Killing | 25 | µM | target cell: Monkey kidney epithelial cells LLC-MK2

Target

Monkey kidney epithelial cells LLC-MK2

Source & Reference

NA
DBAASP
In Vitro and In Vivo Anti- Candida Activity and Structural Analysis of Killer Peptide (KP)-Derivatives. | J Fungi (Basel) | 2021
Evidence 4 Activity

Activity

9.01% Killing
Toxicity
50 µM
Cytotoxic
9.01% Killing | 50 | µM | target cell: Monkey kidney epithelial cells LLC-MK2

Target

Monkey kidney epithelial cells LLC-MK2

Source & Reference

NA
DBAASP
In Vitro and In Vivo Anti- Candida Activity and Structural Analysis of Killer Peptide (KP)-Derivatives. | J Fungi (Basel) | 2021