TPDB

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB21044

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

Peptipedia Antifungipept CAFPdb dbAMP

Sequence_Type

standard

Has_Modification No

Description A 63-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia, Antifungipept, CAFPdb, and other sources, with an available 3D structural model.

Sequence

HHLFGKVGREIERSAHKVGHKLEHVRHEVSKTAKKVDKVVGHIKTAKKVVAAAGAIAGVVAAA

FASTA

>TPDB21044|Antibacterial;Antifungal|length=63
HHLFGKVGREIERSAHKVGHKLEHVRHEVSKTAKKVDKVVGHIKTAKKVVAAAGAIAGVVAAA

Formula C297H500N96O78

Absent Amino Acids NCQMPWY

Common Amino Acids AV

Mass 6663.83

PI 10.86

Basic Residues 20

Acidic Residues 5

Hydrophobic Residues 28

Net Charge +9

Boman Index 24.68

Hydrophobicity -0.125

Aliphatic Index 99.05

Half Life

Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour

Extinction Coefficient Cystines 0

Absorbance 280nm 0.00

Polar Residues 4

number

11

A

3

R

0

N

1

D

0

C

4

E

0

Q

6

G

7

H

3

I

2

L

10

K

0

M

1

F

0

P

2

S

2

T

0

W

0

Y

11

V

Amino Acid Distribution

A: 11 R: 3 N: 0 D: 1 C: 0 E: 4 Q: 0 G: 6 H: 7 I: 3 L: 2 K: 10 M: 0 F: 1 P: 0 S: 2 T: 2 W: 0 Y: 0 V: 11

Length

63

Formula

C297H500N96O78

Mass

6663.83

PI

10.86

Net Charge

+9

Boman Index

24.68

Hydrophobicity

-0.125

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 3.6 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against E. coli (MIC 3.6 uM) and M. luteus (MIC 70.0 uM).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 70.0 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against E. coli (MIC 3.6 uM) and M. luteus (MIC 70.0 uM).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 3.6 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against E. coli (MIC 3.6 uM) and M. luteus (MIC 70.0 uM).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 70.0 µM

Target

Target Organism M. luteus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 3.6 uM) and M. luteus (MIC 70.0 uM).