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Peptide record

TPDB21028

Antibacterial Antifungal Toxicity standard
33 amino acids
Basic Information
3D PDB MODEL
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TPDB21028
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
standard
No
A 33-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Sequence
HFSLILSDCKTNKDCPKLRRANVRCRKSYCVPI
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C166H279N53O45S4
EQGMW
RCK
3865.61
9.99
9
2
10
+6
2.65
-0.455
79.70
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
1740
0.45
11
Residue Composition
number
1
A
4
R
2
N
2
D
4
C
0
E
0
Q
0
G
1
H
2
I
3
L
4
K
0
M
1
F
2
P
3
S
1
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 4 N: 2 D: 2 C: 4 E: 0 Q: 0 G: 0 H: 1 I: 2 L: 3 K: 4 M: 0 F: 1 P: 2 S: 3 T: 1 W: 0 Y: 1 V: 2
Chemical Descriptors
33 reviewed residue count
C166H279N53O45S4 sequence-only estimate (linear, free termini)
3865.61 sequence-only estimate (linear, free termini)
9.99 sequence-only estimate (linear, free termini)
+6 sequence-only estimate (linear, free termini)
2.65 sequence-only estimate (linear, free termini)
-0.455 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

20% Killing
Toxicity
25 µM
Cytotoxic
20% Killing | 25 | µM | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Symbiotic NCR Peptide Fragments Affect the Viability, Morphology and Biofilm Formation of Candida Species. | Int J Mol Sci | 2021