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Peptide record

TPDB20986

L2 Antibacterial Anticancer Blood-Brain Barrier Cell-penetrating Peptides Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB20986
L2
Antibacterial Anticancer Blood-Brain Barrier Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
Peptipedia CancerPPD 2.0 BBPpredict CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 PerseuCPP
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, Blood-Brain Barrier, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, BBPpredict, and other sources, with an available 3D structural model.
Sequence
HARIKPTFRRLKWKYKGKFW
Physicochemical Analysis
C129H196N38O23
NDCEQMSV
K
2647.22
12.17
9
0
8
+8
1.00
-1.315
44.00
Mammalian: 3.5 hour Yeast: 10 min E.coli: >10 hour
12490
471.82
2
Residue Composition
number
1
A
3
R
0
N
0
D
0
C
0
E
0
Q
1
G
1
H
1
I
1
L
5
K
0
M
2
F
1
P
0
S
1
T
2
W
1
Y
0
V
Amino Acid Distribution
A: 1 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 1 L: 1 K: 5 M: 0 F: 2 P: 1 S: 0 T: 1 W: 2 Y: 1 V: 0
Chemical Descriptors
20
C129H196N38O23
2647.22
12.17
+8
1.00
-1.315
Free
L
Linear
Free
N[C@@H](CC1=NC=NC1)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC1=CN=C(C)/C/1=C\C)C(=O)O
Evidence Records 3 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7 And H460

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L
Synthetic
In vitro
CCCCCTTSSSCCCCSSSCC
Evidence 2 Activity

Activity

IC50
Toxicity
234±9 µM
Cytotoxic
IC50 | 234±9 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
The Antitumor Peptide CIGB-552 Increases COMMD1 and Inhibits Growth of Human Lung Cancer Cells. | J Amino Acids | 2013
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
J Amino Acids. 2013 2013:251398.
Additional Detail Fields 1 fields
CCCCCTTSSSCCCCSSSCC