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Peptide record

TPDB20952

Antibacterial Anticancer Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB20952
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia SATPdb
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and SATPdb, with an available 3D structural model.
Sequence
GWRKWIKKATHVGKHIGKAALDAYI
Physicochemical Analysis
C134H211N39O30
NCEQMFPS
K
2848.39
10.76
8
1
12
+5
2.34
-0.408
90.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
12490
438.49
2
Residue Composition
number
4
A
1
R
0
N
1
D
0
C
0
E
0
Q
3
G
2
H
3
I
1
L
5
K
0
M
0
F
0
P
0
S
1
T
2
W
1
Y
1
V
Amino Acid Distribution
A: 4 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 3 H: 2 I: 3 L: 1 K: 5 M: 0 F: 0 P: 0 S: 0 T: 1 W: 2 Y: 1 V: 1
Chemical Descriptors
25
C134H211N39O30
2848.39
10.76
+5
2.34
-0.408
Evidence Records 4 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
>256 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >256 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 2 Activity

Activity

>10% Killing
Toxicity
5 µM
Cytotoxic
>10% Killing | 5 | µM | target cell: Zebrafish embryos

Target

Zebrafish embryos

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 3 Activity

Activity

0% Killing
Toxicity
25 µM
Cytotoxic
0% Killing | 25 | µM | target cell: Zebrafish embryos

Target

Zebrafish embryos

Source & Reference

NA
DBAASP
The zebrafish embryo as a tool for screening and characterizing pleurocidin host-defense peptides as anti-cancer agents. | Dis Model Mech | 2011
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
50 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 50% Hemolysis>256 µg/ml | Cytotoxicity: Zebrafish embryos: >10% Killing=5 µg/ml (4, 52hpf embryo)

Target

erythrocytes

Source & Reference

NA
DRAMP
Dis Model Mech. 2011 Sep 4(5):622-33.