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Peptide record

TPDB20908

Antibacterial Anticancer Antifungal Toxicity modified_plain modified
18 amino acids
Basic Information
3D PDB MODEL
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TPDB20908
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 18-aa modified multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
GXRRLXYKQRXVTYXRGR
Physicochemical Analysis
C78H133N31O19
ANDCEHIMFPSW
R
1809.11
12.24
6
0
4
+6
3.41
-1.444
37.78
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
2980
164.72
4
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
1
Q
2
G
0
H
0
I
1
L
1
K
0
M
0
F
0
P
0
S
1
T
0
W
2
Y
1
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 1 G: 2 H: 0 I: 0 L: 1 K: 1 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 2 V: 1
Chemical Descriptors
18
C78H133N31O19
1809.11
12.24
+6
3.41
-1.444
Evidence Records 4 records
Evidence 1 Activity

Activity

32.8±0.5% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
32.8±0.5% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 2 Activity

Activity

CC50
Toxicity
15.6±3.6 µM
Cytotoxic
CC50 | 15.6±3.6 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 3 Activity

Activity

CC50
Toxicity
15.5±0.8 µM
Cytotoxic
CC50 | 15.5±0.8 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Redesigned Spider Peptide with Improved Antimicrobial and Anticancer Properties. | ACS Chem Biol | 2017
Evidence 4 Activity

Activity

% Hemolysis
Toxicity
0.5 %
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: 32.8±0.5% Hemolysis=64µM | Cytotoxicity: HFF-1: CC50=15.6±3.6µM PBMC: CC50=15.5±0.8µM

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Chem Biol. 2017 Sep 15 12(9):2324-2334.