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Peptide record

TPDB20894

Antibacterial Antifungal Toxicity modified_plain modified
10 amino acids
Basic Information
3D PDB MODEL
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TPDB20894
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
modified_plain
Yes
A 10-aa modified multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Modified, details unspecified
Sequence
GXLKRIKTLL
Physicochemical Analysis
C48H92N14O11
ANDCEQHMFPSWYV
L
1041.35
11.64
3
0
4
+3
0.95
0.250
156.00
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
1
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
1
I
3
L
2
K
0
M
0
F
0
P
0
S
1
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 3 K: 2 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 0 V: 0
Chemical Descriptors
10
C48H92N14O11
1041.35
11.64
+3
0.95
0.250
Evidence Records 6 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
<5% Hemolysis | 256 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Synthesis and anti-pseudomonal activity of new ß-Ala modified analogues of the antimicrobial peptide anoplin | Int J Med Microbiol | 2020
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
52.75 µM
Hemolytic Cytotoxic
50% Hemolysis | 52.75 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthetic analogs of anoplin show improved antimicrobial activities. | J Pept Sci | 2013
Evidence 3 Activity

Activity

50% Hemolysis
Toxicity
108 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 108 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Improving the biological activity of the antimicrobial peptide anoplin by membrane anchoring through a lipophilic amino acid derivative. | Bioorg Med Chem Lett | 2013
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
194.75 µM
Hemolytic Cytotoxic
50% Hemolysis | 194.75 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Synthetic analogs of anoplin show improved antimicrobial activities. | J Pept Sci | 2013
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
>500 µM
Hemolytic Cytotoxic
50% Hemolysis | >500 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rational design of alpha-helical antimicrobial peptides: do's and don'ts. | Chembiochem | 2015
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
300 µM
Hemolytic Cytotoxic
50% Hemolysis | 300 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Rational design of alpha-helical antimicrobial peptides: do's and don'ts. | Chembiochem | 2015