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Peptide record

TPDB20872

Antibacterial Toxicity modified_plain modified
25 amino acids
Basic Information
3D PDB MODEL
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TPDB20872
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 25-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
GXGSFXKKKAHVGKHXGKAXLTHYL
Physicochemical Analysis
C104H166N32O25
RNDCEQIMPW
K
2264.66
10.77
8
0
7
+5
4.68
-0.612
50.80
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1490
65.79
3
Residue Composition
number
2
A
0
R
0
N
0
D
0
C
0
E
0
Q
4
G
3
H
0
I
2
L
5
K
0
M
1
F
0
P
1
S
1
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 2 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 3 I: 0 L: 2 K: 5 M: 0 F: 1 P: 0 S: 1 T: 1 W: 0 Y: 1 V: 1
Chemical Descriptors
25
C104H166N32O25
2264.66
10.77
+5
4.68
-0.612
Evidence Records 1 records
Evidence 1 Activity

Activity

17.1% Hemolysis
Toxicity
25 µg/mL
Hemolytic Cytotoxic
17.1% Hemolysis | 25 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice. | Nat Biotechnol | 2019