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Peptide record

TPDB20867

Antibacterial Toxicity modified_plain modified
23 amino acids
Basic Information
3D PDB MODEL
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TPDB20867
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 23-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
GXGKFXHSKKKFGKAXVGEXXNS
Physicochemical Analysis
C85H136N26O24
RDCQILMPTWY
K
1906.17
10.71
6
1
4
+4
6.29
-0.926
16.96
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
3
Residue Composition
number
1
A
0
R
1
N
0
D
0
C
1
E
0
Q
4
G
1
H
0
I
0
L
5
K
0
M
2
F
0
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 1 R: 0 N: 1 D: 0 C: 0 E: 1 Q: 0 G: 4 H: 1 I: 0 L: 0 K: 5 M: 0 F: 2 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
23
C85H136N26O24
1906.17
10.71
+4
6.29
-0.926
Evidence Records 3 records
Evidence 1 Activity

Activity

5% Hemolysis
Toxicity
200 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 200 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice. | Nat Biotechnol | 2019
Evidence 2 Activity

Activity

18% Hemolysis
Toxicity
400 µg/mL
Hemolytic Cytotoxic
18% Hemolysis | 400 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice. | Nat Biotechnol | 2019
Evidence 3 Activity

Activity

74.9% Cytotoxicity
Toxicity
100 µg/mL
Cytotoxic
74.9% Cytotoxicity | 100 | µg/mL | target cell: Human renal proximal tubular epithelial cells (HRPTEC)

Target

Human renal proximal tubular epithelial cells (HRPTEC)

Source & Reference

NA
DBAASP
Design of stapled antimicrobial peptides that are stable, nontoxic and kill antibiotic-resistant bacteria in mice. | Nat Biotechnol | 2019