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Peptide record

TPDB20852

Antibacterial Anticancer Hemolysis Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB20852
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia PD_Hemolysis
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from Peptipedia and PD_Hemolysis, with an available 3D structural model.
Sequence
GWYEIIKKIYKWLK
Physicochemical Analysis
C95H142N20O19
ARNDCQHMFPSTV
K
1868.30
10.13
4
1
8
+3
-1.08
-0.471
111.43
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
13980
748.28
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
1
E
0
Q
1
G
0
H
3
I
1
L
4
K
0
M
0
F
0
P
0
S
0
T
2
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 1 Q: 0 G: 1 H: 0 I: 3 L: 1 K: 4 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 2 V: 0
Chemical Descriptors
14
C95H142N20O19
1868.30
10.13
+3
-1.08
-0.471
Evidence Records 4 records
Evidence 1 Activity

Activity

EC50
Toxicity
6.6 µM
Cytotoxic
EC50 | 6.6 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
Simulated Molecular Evolution for Anticancer Peptide Design. | Angew Chem Int Ed Engl | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
5.2±0.2 µM
Hemolytic Cytotoxic
50% Hemolysis | 5.2±0.2 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Simulated Molecular Evolution for Anticancer Peptide Design. | Angew Chem Int Ed Engl | 2019
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Angew Chem Int Ed Engl. 2019 Feb 4 58(6):1674-1681.
Evidence 4 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis