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Peptide record

TPDB20850

Antibacterial Anticancer Antifungal Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB20850
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GWWRRTVKKVRNAVRKV
Physicochemical Analysis
C97H163N35O20
DCEQHILMFPSY
RV
2139.58
12.88
7
0
7
+7
3.19
-1.029
74.12
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
514.12
2
Residue Composition
number
1
A
4
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
3
K
0
M
0
F
0
P
0
S
1
T
2
W
0
Y
4
V
Amino Acid Distribution
A: 1 R: 4 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 3 M: 0 F: 0 P: 0 S: 0 T: 1 W: 2 Y: 0 V: 4
Chemical Descriptors
17
C97H163N35O20
2139.58
12.88
+7
3.19
-1.029
Evidence Records 3 records
Evidence 1 Activity

Activity

IC50
Toxicity
450 µg/mL
Cytotoxic
IC50 | 450 | µg/mL | target cell: Human gastric epithelial cells GES-1

Target

Human gastric epithelial cells GES-1

Source & Reference

NA
DBAASP
Antimicrobial and antibiofilm activity of the EeCentrocin 1 derived peptide EC1-17KV via membrane disruption. | EBioMedicine | 2020
Evidence 2 Activity

Activity

IC50
Toxicity
530 µg/mL
Cytotoxic
IC50 | 530 | µg/mL | target cell: Human hepatocyte cells HL-7702 (L02)

Target

Human hepatocyte cells HL-7702 (L02)

Source & Reference

NA
DBAASP
Antimicrobial and antibiofilm activity of the EeCentrocin 1 derived peptide EC1-17KV via membrane disruption. | EBioMedicine | 2020
Evidence 3 Activity

Activity

<2% Hemolysis
Toxicity
512 µg/mL
Hemolytic Cytotoxic
<2% Hemolysis | 512 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial and antibiofilm activity of the EeCentrocin 1 derived peptide EC1-17KV via membrane disruption. | EBioMedicine | 2020