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Peptide record

TPDB20843

Antibacterial Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB20843
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 31-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GWLSKTWKKLENSAKKRIAEGIAIAIRGGPR
Physicochemical Analysis
C155H260N48O40
DCQHMFYV
K
3436.07
11.58
8
2
12
+6
5.99
-0.581
88.39
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
11000
320.13
4
Residue Composition
number
4
A
3
R
1
N
0
D
0
C
2
E
0
Q
4
G
0
H
4
I
2
L
5
K
0
M
0
F
1
P
2
S
1
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 4 R: 3 N: 1 D: 0 C: 0 E: 2 Q: 0 G: 4 H: 0 I: 4 L: 2 K: 5 M: 0 F: 0 P: 1 S: 2 T: 1 W: 2 Y: 0 V: 0
Chemical Descriptors
31
C155H260N48O40
3436.07
11.58
+6
5.99
-0.581
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.5-2 µM

Target

i.2

Source & Reference

NA

Other

Active against E. coli ATCC, c.i., or c.i.2 (MIC 0.5-2 uM), K. pneumoniae ATCC, c.i., c.i.2 (MIC 0.5-2 uM), A. baumannii ATCC, c.i., or c.i.2. (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
0.5-2 µM

Target

i.2

Source & Reference

NA

Other

Active against E. coli ATCC, c.i., or c.i.2 (MIC 0.5-2 uM), K. pneumoniae ATCC, c.i., c.i.2 (MIC 0.5-2 uM), A. baumannii ATCC, c.i., or c.i.2. (MIC 0.5-2 uM), P. aeruginosa ATCC, c.i., or c.i.2 (M
Evidence 3 Activity

Activity

MIC
Antibacterial
2-4 µM

Target

i.2

Source & Reference

NA

Other

-2 uM), A. baumannii ATCC, c.i., or c.i.2. (MIC 0.5-2 uM), P. aeruginosa ATCC, c.i., or c.i.2 (MIC 2-4 uM), and S. aureus ATCC (MIC 2 uM), S-aureus c.i., or c.i.2 (MIC >64 uM). All MBC values are
Evidence 4 Activity

Activity

MIC
Antibacterial
2 µM

Target

Staphylococcus aureus ATCC

Source & Reference

NA

Other

TCC, c.i., or c.i.2. (MIC 0.5-2 uM), P. aeruginosa ATCC, c.i., or c.i.2 (MIC 2-4 uM), and S. aureus ATCC (MIC 2 uM), S-aureus c.i., or c.i.2 (MIC >64 uM). All MBC values are similar to MIC values, indicati
Evidence 5 Activity

Activity

MIC
Antibacterial
>64 µM

Target

i.2

Source & Reference

NA

Other

osa ATCC, c.i., or c.i.2 (MIC 2-4 uM), and S. aureus ATCC (MIC 2 uM), S-aureus c.i., or c.i.2 (MIC >64 uM). All MBC values are similar to MIC values, indicative of a bactericidal effect.
Evidence 6 Activity

Activity

LC50
Toxicity
>100 µM
Cytotoxic
LC50 | >100 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Anisaxins, helical antimicrobial peptides from marine parasites, kill resistant bacteria by lipid extraction and membrane disruption. | Acta Biomater | 2022