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Peptide record

TPDB20828

Antibacterial Antifungal Toxicity standard
23 amino acids
Basic Information
3D PDB MODEL
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TPDB20828
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia AFP-GFuse CAFPdb dbAMP
standard
No
A 23-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia, AFP-GFuse, CAFPdb, and other sources, with an available 3D structural model.
Sequence
GWLIRGAIHAGKAIHGLIHRRRH
Physicochemical Analysis
C118H193N45O24
NDCEQMFPSTYV
RGHI
2626.12
12.88
9
0
10
+5
3.39
-0.270
114.78
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
209.43
0
Residue Composition
number
3
A
4
R
0
N
0
D
0
C
0
E
0
Q
4
G
4
H
4
I
2
L
1
K
0
M
0
F
0
P
0
S
0
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 4 I: 4 L: 2 K: 1 M: 0 F: 0 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 0
Chemical Descriptors
23
C118H193N45O24
2626.12
12.88
+5
3.39
-0.270
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
50 ug/mL

Target

Candida albicans

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Weakly active against C. albicans (MIC 50 ug/mL), which was essentially all killed at 100 ug/ml (MFC). Also showed significant activity ag
Evidence 2 Activity

Activity

MIC
Antibacterial
4-8 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP

Other

killed at 100 ug/ml (MFC). Also showed significant activity against carbapenem-resistant E. coli (MIC 4-8 ug/ml) MBC higher (see the 2023 Kong ref).
Evidence 3 Activity

Activity

MIC
Antifungal
50 ug/mL

Target

Candida albicans

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Weakly active against C. albicans (MIC 50 ug/mL), which was essentially all killed at 100 ug/ml (MFC). Also showed significant activity ag
Evidence 4 Activity

Activity

MIC
Antifungal
4-8 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb

Other

killed at 100 ug/ml (MFC). Also showed significant activity against carbapenem-resistant E. coli (MIC 4-8 ug/ml) MBC higher (see the 2023 Kong ref).
Evidence 5 Activity

Activity

5% Killing
Toxicity
100 µg/mL
Cytotoxic
5% Killing | 100 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Octominin: A Novel Synthetic Anticandidal Peptide Derived from Defense Protein of Octopus minor. | Mar Drugs | 2020