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Peptide record

TPDB20825

Antibacterial Antifungal Toxicity standard
95 amino acids
Basic Information
3D PDB MODEL
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TPDB20825
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia Antifungipept
standard
No
A 95-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia and Antifungipept, with an available 3D structural model.
Sequence
GWLDRIIGTAVDSVAEFGTTNIVDQICNTRVMPTIKKFELYFRGRVWCPGWTTIQGESLTRSRTRVVNKAVEDFARKAVAAGLMTQEDANPLLNA
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C468H748N134O138S4
H
T
10588.14
8.99
12
10
40
+2
1.69
-0.124
86.21
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
18115
1.71
24
Residue Composition
number
9
A
8
R
5
N
5
D
2
C
5
E
3
Q
7
G
0
H
6
I
6
L
4
K
2
M
4
F
3
P
3
S
10
T
3
W
1
Y
9
V
Amino Acid Distribution
A: 9 R: 8 N: 5 D: 5 C: 2 E: 5 Q: 3 G: 7 H: 0 I: 6 L: 6 K: 4 M: 2 F: 4 P: 3 S: 3 T: 10 W: 3 Y: 1 V: 9
Chemical Descriptors
95 reviewed residue count
C468H748N134O138S4 sequence-only estimate (linear, free termini)
10588.14 sequence-only estimate (linear, free termini)
8.99 sequence-only estimate (linear, free termini)
+2 sequence-only estimate (linear, free termini)
1.69 sequence-only estimate (linear, free termini)
-0.124 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

Active against Gram- bacteria V. anguillarum (80% killing), E. coli Top10F’(26% killing), and Gram+ bacteria M. luteus (MBC 6.9 uM 100% killing) at 6.9 uM.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

Antifungipept

Other

Active against Gram- bacteria V. anguillarum (80% killing), E. coli Top10F’(26% killing), and Gram+ bacteria M. luteus (MBC 6.9 uM 100% killing) at 6.9 uM.