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Peptide record

TPDB20803

Antibacterial Anticancer Toxicity standard
25 amino acids
Basic Information
3D PDB MODEL
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TPDB20803
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 25-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GWGSFFRRAAHVGRHVGRAALTHYL
Physicochemical Analysis
C129H192N44O29
NDCEQIKMP
ARG
2823.22
12.40
7
0
12
+4
-0.28
-0.164
70.40
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
6990
247.59
3
Residue Composition
number
4
A
4
R
0
N
0
D
0
C
0
E
0
Q
4
G
3
H
0
I
2
L
0
K
0
M
2
F
0
P
1
S
1
T
1
W
1
Y
2
V
Amino Acid Distribution
A: 4 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 4 H: 3 I: 0 L: 2 K: 0 M: 0 F: 2 P: 0 S: 1 T: 1 W: 1 Y: 1 V: 2
Chemical Descriptors
25
C129H192N44O29
2823.22
12.40
+4
-0.28
-0.164
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2-4 µg/mL

Target

Klebsiella pneumoniae NCTC 13368 or M6

Source & Reference

NA

Other

Active against Gram- K. pneumoniae NCTC 13368 or M6 (MIC 2-4 ug/ml), A. baumannii AYE or ATCC 17978 (MIC 1-2 ug/ml), P. aeruginosa NCTC 13437 or PAO1 (MIC 4-
Evidence 2 Activity

Activity

MIC
Antibacterial
1-2 µg/mL

Target

A. baumannii AYE or ATCC 17978

Source & Reference

NA

Other

Active against Gram- K. pneumoniae NCTC 13368 or M6 (MIC 2-4 ug/ml), A. baumannii AYE or ATCC 17978 (MIC 1-2 ug/ml), P. aeruginosa NCTC 13437 or PAO1 (MIC 4-8 ug/ml), E. coli NCTC 12923 (MIC 1 ug/ml), Gram
Evidence 3 Activity

Activity

MIC
Antibacterial
4-8 µg/mL

Target

Pseudomonas aeruginosa NCTC 13437 or PAO1

Source & Reference

NA

Other

umoniae NCTC 13368 or M6 (MIC 2-4 ug/ml), A. baumannii AYE or ATCC 17978 (MIC 1-2 ug/ml), P. aeruginosa NCTC 13437 or PAO1 (MIC 4-8 ug/ml), E. coli NCTC 12923 (MIC 1 ug/ml), Gram+ methicillin-sensitive S. aureus ATCC 9144 or MRS
Evidence 4 Activity

Activity

MIC
Antibacterial
1 µg/mL

Target

Escherichia coli NCTC 12923

Source & Reference

NA

Other

nnii AYE or ATCC 17978 (MIC 1-2 ug/ml), P. aeruginosa NCTC 13437 or PAO1 (MIC 4-8 ug/ml), E. coli NCTC 12923 (MIC 1 ug/ml), Gram+ methicillin-sensitive S. aureus ATCC 9144 or MRSA NCTC 13616 or MRSA NCTC 13277 (M
Evidence 5 Activity

Activity

MIC
Antibacterial
2-4 µg/mL

Target

Staphylococcus aureus ATCC 9144 or MRSA NCTC 13616 or MRSA NCTC 13277

Source & Reference

NA

Other

37 or PAO1 (MIC 4-8 ug/ml), E. coli NCTC 12923 (MIC 1 ug/ml), Gram+ methicillin-sensitive S. aureus ATCC 9144 or MRSA NCTC 13616 or MRSA NCTC 13277 (MIC 2-4 ug/ml), vancomycin-sensitive and resistant E. faecalis NCTC 775 or NCTC 12204 (MIC 4-16 ug/ml) (
Evidence 6 Activity

Activity

MIC
Antibacterial
4-16 µg/mL

Target

Enterococcus faecalis NCTC 775 or NCTC 12204

Source & Reference

NA

Other

or MRSA NCTC 13616 or MRSA NCTC 13277 (MIC 2-4 ug/ml), vancomycin-sensitive and resistant E. faecalis NCTC 775 or NCTC 12204 (MIC 4-16 ug/ml) (anti-VRE).
Evidence 7 Activity

Activity

IC50
Toxicity
40.1±4.1 µg/mL
Cytotoxic
IC50 | 40.1±4.1 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
A pleurocidin analogue with greater conformational flexibility, enhanced antimicrobial potency and in vivo therapeutic efficacy. | Commun Biol | 2020
Evidence 8 Activity

Activity

10% Hemolysis
Toxicity
192 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 192 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
A pleurocidin analogue with greater conformational flexibility, enhanced antimicrobial potency and in vivo therapeutic efficacy. | Commun Biol | 2020
Evidence 9 Activity

Activity

IC50
Toxicity
40.1
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: HEK293: IC50=40.1 ± 4.1 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Commun Biol. 2020 Nov 27 3(1):697.