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Peptide record

TPDB20785

Antibacterial Anticancer Toxicity standard
14 amino acids
Basic Information
3D PDB MODEL
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TPDB20785
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 14-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
GWFDILKHVFRLLK
Physicochemical Analysis
C88H134N22O17
ANCEQMPSTY
L
1772.17
10.59
4
1
8
+2
-1.04
0.386
132.14
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
5500
310.35
0
Residue Composition
number
0
A
1
R
0
N
1
D
0
C
0
E
0
Q
1
G
1
H
1
I
3
L
2
K
0
M
2
F
0
P
0
S
0
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 1 H: 1 I: 1 L: 3 K: 2 M: 0 F: 2 P: 0 S: 0 T: 0 W: 1 Y: 0 V: 1
Chemical Descriptors
14
C88H134N22O17
1772.17
10.59
+2
-1.04
0.386
Evidence Records 3 records
Evidence 1 Activity

Activity

EC50
Toxicity
1.5 µM
Cytotoxic
EC50 | 1.5 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
Simulated Molecular Evolution for Anticancer Peptide Design. | Angew Chem Int Ed Engl | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
4.7±0.3 µM
Hemolytic Cytotoxic
50% Hemolysis | 4.7±0.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Simulated Molecular Evolution for Anticancer Peptide Design. | Angew Chem Int Ed Engl | 2019
Evidence 3 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Angew Chem Int Ed Engl. 2019 Feb 4 58(6):1674-1680.