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Peptide record

TPDB20763

Brevinin-2MP Anti-inflammatory Antibacterial Anticancer Antifungal Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB20763
Brevinin-2MP
Anti-inflammatory Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Immunity and inflammation peptides Toxicity and safety peptides
Peptipedia CAFPdb ToxinPred 3.0 DBAASP
standard
No
A 30-aa standard natural multi-activity (Anti-inflammatory, Antibacterial, Anticancer, and other sources) peptide sequence curated from Peptipedia, CAFPdb, ToxinPred 3.0, and other sources, with an available 3D structural model.
Sequence
GVITDTLKGVAKTVAAELLRKAHCKLTNSC
Physicochemical Analysis
C135H238N40O41S2
QMFPWY
ALKT
3141.74
9.71
6
2
12
+3
6.61
0.210
107.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
3.98
8
Residue Composition
number
4
A
1
R
1
N
1
D
2
C
1
E
0
Q
2
G
1
H
1
I
4
L
4
K
0
M
0
F
0
P
1
S
4
T
0
W
0
Y
3
V
Amino Acid Distribution
A: 4 R: 1 N: 1 D: 1 C: 2 E: 1 Q: 0 G: 2 H: 1 I: 1 L: 4 K: 4 M: 0 F: 0 P: 0 S: 1 T: 4 W: 0 Y: 0 V: 3
Chemical Descriptors
30
C135H238N40O41S2
3141.74
9.71
+3
6.61
0.210
Evidence Records 17 records
Evidence 1 Activity

Activity

MIC
Antibacterial
47.78 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

Active against Gram- E. coli ATCC 25922 (MIC 47.78 uM), P.aeruginosa ATCC 27853 (MIC>100 uM), Gram+ S. aureus ATCC 25923 (MIC 47.78 uM), P. acne
Evidence 2 Activity

Activity

MIC
Antibacterial
>100 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

NA

Other

Active against Gram- E. coli ATCC 25922 (MIC 47.78 uM), P.aeruginosa ATCC 27853 (MIC>100 uM), Gram+ S. aureus ATCC 25923 (MIC 47.78 uM), P. acnes ATCC 6919 (MIC 14.93 uM), B. subtili
Evidence 3 Activity

Activity

MIC
Antibacterial
47.78 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

NA

Other

inst Gram- E. coli ATCC 25922 (MIC 47.78 uM), P.aeruginosa ATCC 27853 (MIC>100 uM), Gram+ S. aureus ATCC 25923 (MIC 47.78 uM), P. acnes ATCC 6919 (MIC 14.93 uM), B. subtilis CMCC 63501 (MIC 4.97 uM), and fungi C. al
Evidence 4 Activity

Activity

MIC
Antibacterial
14.93 µM

Target

P. acnes ATCC 6919

Source & Reference

NA

Other

.78 uM), P.aeruginosa ATCC 27853 (MIC>100 uM), Gram+ S. aureus ATCC 25923 (MIC 47.78 uM), P. acnes ATCC 6919 (MIC 14.93 uM), B. subtilis CMCC 63501 (MIC 4.97 uM), and fungi C. albicans ATCC 10231 (MIC 59.73 uM). I
Evidence 5 Activity

Activity

MIC
Antibacterial
4.97 µM

Target

B. subtilis CMCC 63501

Source & Reference

NA

Other

IC>100 uM), Gram+ S. aureus ATCC 25923 (MIC 47.78 uM), P. acnes ATCC 6919 (MIC 14.93 uM), B. subtilis CMCC 63501 (MIC 4.97 uM), and fungi C. albicans ATCC 10231 (MIC 59.73 uM). It also suppresses the LPS-induced expr
Evidence 6 Activity

Activity

MIC
Antibacterial
59.73 µM

Target

Candida albicans ATCC 10231

Source & Reference

NA

Other

8 uM), P. acnes ATCC 6919 (MIC 14.93 uM), B. subtilis CMCC 63501 (MIC 4.97 uM), and fungi C. albicans ATCC 10231 (MIC 59.73 uM). It also suppresses the LPS-induced expression of pro-inflammatory NO, MCP-1, IL-6, and T
Evidence 7 Activity

Activity

MIC
Antifungal
47.78 µM

Target

Escherichia coli ATCC 25922

Source & Reference

CAFPdb

Other

Active against Gram- E. coli ATCC 25922 (MIC 47.78 uM), P.aeruginosa ATCC 27853 (MIC>100 uM), Gram+ S. aureus ATCC 25923 (MIC 47.78 uM), P. acne
Evidence 8 Activity

Activity

MIC
Antifungal
>100 µM

Target

P.aeruginosa ATCC 27853

Source & Reference

CAFPdb

Other

Active against Gram- E. coli ATCC 25922 (MIC 47.78 uM), P.aeruginosa ATCC 27853 (MIC>100 uM), Gram+ S. aureus ATCC 25923 (MIC 47.78 uM), P. acnes ATCC 6919 (MIC 14.93 uM), B. subtili
Evidence 9 Activity

Activity

MIC
Antifungal
47.78 µM

Target

Staphylococcus aureus ATCC 25923

Source & Reference

CAFPdb

Other

inst Gram- E. coli ATCC 25922 (MIC 47.78 uM), P.aeruginosa ATCC 27853 (MIC>100 uM), Gram+ S. aureus ATCC 25923 (MIC 47.78 uM), P. acnes ATCC 6919 (MIC 14.93 uM), B. subtilis CMCC 63501 (MIC 4.97 uM), and fungi C. al
Evidence 10 Activity

Activity

MIC
Antifungal
14.93 µM

Target

P. acnes ATCC 6919

Source & Reference

CAFPdb

Other

.78 uM), P.aeruginosa ATCC 27853 (MIC>100 uM), Gram+ S. aureus ATCC 25923 (MIC 47.78 uM), P. acnes ATCC 6919 (MIC 14.93 uM), B. subtilis CMCC 63501 (MIC 4.97 uM), and fungi C. albicans ATCC 10231 (MIC 59.73 uM). I
Evidence 11 Activity

Activity

MIC
Antifungal
4.97 µM

Target

B. subtilis CMCC 63501

Source & Reference

CAFPdb

Other

IC>100 uM), Gram+ S. aureus ATCC 25923 (MIC 47.78 uM), P. acnes ATCC 6919 (MIC 14.93 uM), B. subtilis CMCC 63501 (MIC 4.97 uM), and fungi C. albicans ATCC 10231 (MIC 59.73 uM). It also suppresses the LPS-induced expr
Evidence 12 Activity

Activity

MIC
Antifungal
59.73 µM

Target

Candida albicans ATCC 10231

Source & Reference

CAFPdb

Other

8 uM), P. acnes ATCC 6919 (MIC 14.93 uM), B. subtilis CMCC 63501 (MIC 4.97 uM), and fungi C. albicans ATCC 10231 (MIC 59.73 uM). It also suppresses the LPS-induced expression of pro-inflammatory NO, MCP-1, IL-6, and T
Evidence 13 Activity

Activity

IC50
Toxicity
60.32±5.67 µM
Cytotoxic
IC50 | 60.32±5.67 | µM | target cell: Mouse splenocytes

Target

Mouse splenocytes

Source & Reference

NA
DBAASP
Antimicrobial and Anti-inflammatory Effects of a Novel Peptide From the Skin of Frog Microhyla pulchra. | Front Pharmacol | 2021
Evidence 14 Activity

Activity

1.42±0.16% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
1.42±0.16% Hemolysis | 100 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial and Anti-inflammatory Effects of a Novel Peptide From the Skin of Frog Microhyla pulchra. | Front Pharmacol | 2021
Evidence 15 Activity

Activity

0.78±0.07% Hemolysis
Toxicity
50 µM
Hemolytic Cytotoxic
0.78±0.07% Hemolysis | 50 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial and Anti-inflammatory Effects of a Novel Peptide From the Skin of Frog Microhyla pulchra. | Front Pharmacol | 2021
Evidence 16 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Front Pharmacol. 2021 Dec 16 12:783108.
Evidence 17 Activity

Target

Cutibacterium acnes

Source & Reference

DBAASP