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Peptide record

TPDB20762

Brevinin-2KP Antibacterial Anticancer Antifungal Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB20762
Brevinin-2KP
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0 dbACP ToxinPred 3.0 DBAASP
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, dbACP, and other sources, with an available 3D structural model.
Sequence
GVITDALKGAAKTVAAELLKKAHCKLTNSC
Physicochemical Analysis
C132H232N38O40S2
RQMFPWY
A
3055.64
9.65
6
2
13
+3
6.24
0.233
104.33
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
125
4.09
7
Residue Composition
number
6
A
0
R
1
N
1
D
2
C
1
E
0
Q
2
G
1
H
1
I
4
L
5
K
0
M
0
F
0
P
1
S
3
T
0
W
0
Y
2
V
Amino Acid Distribution
A: 6 R: 0 N: 1 D: 1 C: 2 E: 1 Q: 0 G: 2 H: 1 I: 1 L: 4 K: 5 M: 0 F: 0 P: 0 S: 1 T: 3 W: 0 Y: 0 V: 2
Chemical Descriptors
30
C132H232N38O40S2
3055.64
9.65
+3
6.24
0.233
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

Weakly active against Gram+ and Gram- bacteria and fungi. This peptide can also brevinin- 2KP can promote degranulation and histamine release from mast cells.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

NA

Other

Weakly active against Gram+ and Gram- bacteria and fungi. This peptide can also brevinin- 2KP can promote degranulation and histamine release from mast cells.
Evidence 3 Activity

Activity

IC50
Toxicity
43.64 µM
Cytotoxic
IC50 | 43.64 | µM | target cell: Human skin fibroblasts

Target

Human skin fibroblasts

Source & Reference

NA
DBAASP
Molecular Cloning and Characterization of a Novel Antimicrobial Peptide from the Skin of Kaloula Pulchra | Curr Pharm Biotechnol | 2022
Evidence 4 Activity

Activity

IC50
Toxicity
69.21 µM
Cytotoxic
IC50 | 69.21 | µM | target cell: Madin-Darby canine kidney cells

Target

Madin-Darby canine kidney cells

Source & Reference

NA
DBAASP
Molecular Cloning and Characterization of a Novel Antimicrobial Peptide from the Skin of Kaloula Pulchra | Curr Pharm Biotechnol | 2022
Evidence 5 Activity

Target

Cutibacterium acnes

Source & Reference

DBAASP