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Peptide record

TPDB20760

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity standard
30 amino acids
Basic Information
3D PDB MODEL
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TPDB20760
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia AntiCP 2.0 iACP-DRLF Antifungipept AI4AVP AVPpred-BWR dbAMP 3.0 DRAMP DRAVP 2.0 APD_complete APD_hemolytic HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0
standard
No
A 30-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, AntiCP 2.0, iACP-DRLF, and other sources, with an available 3D structural model.
Sequence
GVPCGESCVFIPCITGVIGCSCSSNVCYLN
Physicochemical Analysis
C127H202N32O41S6
ARDQHKMW
C
3025.55
3.29
0
1
10
-1
-0.26
1.047
90.67
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1865
61.64
14
Residue Composition
number
0
A
0
R
2
N
0
D
6
C
1
E
0
Q
4
G
0
H
3
I
1
L
0
K
0
M
1
F
2
P
4
S
1
T
0
W
1
Y
4
V
Amino Acid Distribution
A: 0 R: 0 N: 2 D: 0 C: 6 E: 1 Q: 0 G: 4 H: 0 I: 3 L: 1 K: 0 M: 0 F: 1 P: 2 S: 4 T: 1 W: 0 Y: 1 V: 4
Chemical Descriptors
30
C127H202N32O41S6
3025.55
3.29
-1
-0.26
1.047
Evidence Records 5 records
Evidence 1 Activity

Activity

HD50
Hemolysis
9.3 µM
[Ref:18081258] HD50=9.3 µM against human type A red blood cells.

Target

human type A red blood cells

Source & Reference

Hemolytik APD_complete APD_hemolytic PD_Hemolysis
DRAMP4
J Nat Prod. 2008 Jan 71(1):47-52.##Biopolymers. 2008 90(1):51-60.##Chembiochem. 2008 Aug 11 9(12):1939-45. doi: 10.1002/cbic.200800174.

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation. Hemolytik experimentally validated hemolytic peptide annotation.
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
9.3 µM
Hemolytic Cytotoxic
50% Hemolysis | 9.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis | J Nat Prod | 2008
Evidence 3 Activity

Activity

IC50
Toxicity
1.7 µM
Cytotoxic
IC50 | 1.7 | µM | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Anti-HIV cyclotides from the Chinese medicinal herb Viola yedoensis | J Nat Prod | 2008
Evidence 4 Activity

Activity

HD50
Toxicity
9.3 µM
Hemolytic Cytotoxic
Hemolytic_activity: [Ref:18081258] HD50=9.3 µM against human type A red blood cells. | Cytotoxicity: [Ref.18008336]CEM-SS cells:IC50=1720 nM.

Target

erythrocytes

Source & Reference

NA
DRAMP
J Nat Prod. 2008 Jan 71(1):47-52.##Biopolymers. 2008 90(1):51-60.##Chembiochem. 2008 Aug 11 9(12):1939-45. doi: 10.1002/cbic.200800174.
Evidence 5 Hemolysis

Activity

9.3 µM
HD50
[Ref:18081258] HD50=9.3 µM against human type A red blood cells.
Hemolysis

Target

human type A red blood cells

Source & Reference

APD_complete APD_hemolytic HemoPI PD_Hemolysis
J Nat Prod. 2008 Jan 71(1):47-52.##Biopolymers. 2008 90(1):51-60.##Chembiochem. 2008 Aug 11 9(12):1939-45. doi: 10.1002/cbic.200800174.
DRAMP4
APD_complete APD_hemolytic PD_Hemolysis

Other

Source Activity Label Source Definition
Hemolysis
APD_complete APD-derived hemolytic peptide annotation. APD_hemolytic APD hemolytic peptide annotation.