TPDB

3D PDB MODEL

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TPDB ID TPDB20693

Activity

Antibacterial Anticancer Hemolysis Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia HemoPI Hemolytic2 PD_Hemolysis ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 31-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from Peptipedia, HemoPI, Hemolytic2, and other sources, with an available 3D structural model.

Sequence

GTLPCGESCVWIPCISSVVGCACKSKVCYKD

FASTA

>TPDB20693|Antibacterial;Anticancer;Hemolysis;Toxicity|length=31
GTLPCGESCVWIPCISSVVGCACKSKVCYKD

Formula C138H223N35O42S6

Absent Amino Acids RNQHMF

Common Amino Acids C

Mass 3236.86

PI 7.62

Basic Residues 3

Acidic Residues 2

Hydrophobic Residues 10

Net Charge +1

Boman Index 2.51

Hydrophobicity 0.555

Aliphatic Index 78.39

Half Life

Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 7365

Absorbance 280nm 227.54

Polar Residues 12

number

1

A

0

R

0

N

1

D

6

C

1

E

0

Q

3

G

0

H

2

I

1

L

3

K

0

M

0

F

2

P

4

S

1

T

1

W

1

Y

4

V

Amino Acid Distribution

A: 1 R: 0 N: 0 D: 1 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 2 L: 1 K: 3 M: 0 F: 0 P: 2 S: 4 T: 1 W: 1 Y: 1 V: 4

Length

31

Formula

C138H223N35O42S6

Mass

3236.86

PI

7.62

Net Charge

+1

Boman Index

2.51

Hydrophobicity

0.555

Evidence 1 Activity

Activity

Activity Endpoint HC50

Detail Source Activity Hemolysis

Activity Measurement 10.00 µM

Hemolysis Raw

HRBCs: HC50=10.00 µM

Source & Reference

Database Source Hemolytik PD_Hemolysis

Source DRAMP4

Reference

Peptides. 2010 Aug 31(8):1434-40.

Other

Source Activity Label	Source Definition
Hemolysis	Hemolytik experimentally validated hemolytic peptide annotation.

Evidence 2 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 10.00 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | 10.00 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Evidence 3 Activity

Activity

Activity Endpoint HC50

Detail Source Activity Toxicity

Activity Measurement 10.00 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

Hemolytic_activity: HRBCs: HC50=10.00 µM | Cytotoxicity: Not available

Target

Target Cell erythrocytes

Source & Reference

Database Source NA

Source Database DRAMP

Reference

Peptides. 2010 Aug 31(8):1434-40.

Evidence 4 Hemolysis

Activity

Activity Measurement 10.00 µM

Activity Endpoint HC50

Hemolysis Raw

HRBCs: HC50=10.00 µM

Detail Source Activity Hemolysis

Source & Reference

source HemoPI PD_Hemolysis

Reference

Peptides. 2010 Aug 31(8):1434-40.

Source DRAMP4

Database Source PD_Hemolysis