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Peptide record

TPDB20681

Antibacterial Anticancer Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB20681
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and ToxinPred 3.0, with an available 3D structural model.
Sequence
GSIPCGESCVFIPCISAIIGCSCSNKVCYKN
Physicochemical Analysis
C135H219N35O42S6
RDQHLMTW
C
3196.79
7.62
2
1
10
+1
1.33
0.726
84.84
Mammalian: 30 hour Yeast: >20 hour E.coli: >10 hour
1865
58.34
14
Residue Composition
number
1
A
0
R
2
N
0
D
6
C
1
E
0
Q
3
G
0
H
5
I
0
L
2
K
0
M
1
F
2
P
5
S
0
T
0
W
1
Y
2
V
Amino Acid Distribution
A: 1 R: 0 N: 2 D: 0 C: 6 E: 1 Q: 0 G: 3 H: 0 I: 5 L: 0 K: 2 M: 0 F: 1 P: 2 S: 5 T: 0 W: 0 Y: 1 V: 2
Chemical Descriptors
31
C135H219N35O42S6
3196.79
7.62
+1
1.33
0.726
Evidence Records 2 records
Evidence 1 Activity

Activity

IC50
Toxicity
1.76±0.12 µM
Cytotoxic
IC50 | 1.76±0.12 | µM | target cell: Human foreskin fibroblasts (HFF)

Target

Human foreskin fibroblasts (HFF)

Source & Reference

NA
DBAASP
Isolation and characterization of cytotoxic cyclotides from Viola philippica. | Peptides | 2011
Evidence 2 Activity

Activity

IC50
Toxicity
1.76
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: HFF-1: IC50=1.76±0.12µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2011 Aug 32(8):1719-23.